ArticleACS chemical biology2013
Transcriptional silencing by single-stranded RNAs targeting a noncoding RNA that overlaps a gene promoter.
Article in ACS chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Optimization in Chemical Modification of Single-Stranded siRNA Encapsulated by Neutral Cytidinyl/Cationic Lipids.Frontiers in chemistry · 2022Article
- siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference.Genes · 2021Article
- Review
- Long Non-Coding RNA Modulation of VEGF-A during Hypoxia.Non-coding RNA · 2018Article
- Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs.Nucleic acid therapeutics · 2017Article
- Argonaute 2-dependent Regulation of Gene Expression by Single-stranded miRNA Mimics.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin.Biochemistry · 2016Review
- DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD.Human molecular genetics · 2015Article
- Modulation of Splicing by Single-Stranded Silencing RNAs.Nucleic acid therapeutics · 2015Article
- Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs.Molecular therapy. Nucleic acids · 2015Article
- An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment.Molecular cell · 2014Article
- Argonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells.Cell death & disease · 2013Article
- ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.Nucleic acids research · 2013Article
- Article
- Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
RNAi using single-strand RNA would provide new options for therapeutic development and for investigating critical questions of mechanism. Using chemically modified single-strands, we test the hypothesis that single-stranded RNAs can engage the RNAi pathway and silence gene transcription. We find that a chemically modified single-stranded silencing RNA (ss-siRNA) designed to be complementary to a long noncoding RNA (lncRNA) requires argonaute protein, functions through the RNAi pathway, and inhibits gene transcription. These data expand the use of single-stranded RNA to cell nuclei.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.