ArticleJournal of the American Chemical Society2012
High-density reconstitution of functional water channels into vesicular and planar block copolymer membranes.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 126 citations in OpenAlex.
- Functional Insertion of the Light-Induced Ion Pump KR2 into Block Copolymer Membranes.Biomacromolecules · 2026Article
- Nanopore-Functionalized Hybrid Lipid-Block Copolymer Membranes Allow Efficient Single-Molecule Sampling and Stable Sensing of Human Serum.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- A Practical Approach for Polarity and Quantity Controlled Assembly of Membrane Proteins into Nanoliposomes.Chembiochem : a European journal of chemical biology · 2025Article
- Unraveling the Phase Behavior, Mechanical Stability, and Protein Reconstitution Properties of Polymer-Lipid Hybrid Vesicles.Biomacromolecules · 2023Article
- Application of polymersomes in membrane protein study and drug discovery: Progress, strategies, and perspectives.Bioengineering & translational medicine · 2023Review
- The energetic barrier to single-file water flow through narrow channels.Biophysical reviews · 2021Review
- Certain, but Not All, Tetraether Lipids from the Thermoacidophilic ArchaeonInternational journal of molecular sciences · 2021Article
- Probing and Tuning the Permeability of Polymersomes.ACS central science · 2021Review
- Investigating the Mechanisms of AquaporinZ Reconstitution through Polymeric Vesicle Composition for a Biomimetic Membrane.Polymers · 2020Article
- Amphipathic Janus Membrane with Hierarchical Multiscale Hyperporous Structure for Interfacial Catalysis.Membranes · 2020Article
- Rapid fabrication of precise high-throughput filters from membrane protein nanosheets.Nature materials · 2020Article
- Article
- Precise nanofiltration in a fouling-resistant self-assembled membrane with water-continuous transport pathways.Science advances · 2019Article
- Increasing Salt Rejection of Polybenzimidazole Nanofiltration Membranes via the Addition of Immobilized and Aligned Aquaporins.Processes (Basel, Switzerland) · 2019Article
- Single-file transport of water through membrane channels.Faraday discussions · 2018Article
- Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes.Nature communications · 2018Article
- Quantification of Water Flux in Vesicular Systems.Scientific reports · 2018Article
- Permselectivity limits of biomimetic desalination membranes.Science advances · 2018Article
- High-flux water desalination with interfacial salt sieving effect in nanoporous carbon composite membranes.Nature nanotechnology · 2018Article
- Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment.Nature communications · 2018Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The exquisite selectivity and unique transport properties of membrane proteins can be harnessed for a variety of engineering and biomedical applications if suitable membranes can be produced. Amphiphilic block copolymers (BCPs), developed as stable lipid analogs, form membranes that functionally incorporate membrane proteins and are ideal for such applications. While high protein density and planar membrane morphology are most desirable, BCP-membrane protein aggregates have so far been limited to low protein densities in either vesicular or bilayer morphologies. Here, we used dialysis to reproducibly form planar and vesicular BCP membranes with a high density of reconstituted aquaporin-0 (AQP0) water channels. We show that AQP0 retains its biological activity when incorporated at high density in BCP membranes, and that the morphology of the BCP-protein aggregates can be controlled by adjusting the amount of incorporated AQP0. We also show that BCPs can be used to form two-dimensional crystals of AQP0.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.