ArticleDiagnostic pathology2012
A comprehensive morphological study for basal-like breast carcinomas with comparison to nonbasal-like carcinomas.
Article in Diagnostic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 39 citations in OpenAlex.
- Protooncogenic Role ofBioMed research international · 2023Article
- Prevalence and Molecular Profile of Breast Carcinoma Using Immunohistochemistry Markers in Mexican Women.World journal of oncology · 2021Article
- Morphological and pathological features of basal-like breast cancer.Translational cancer research · 2019Review
- Article
- The Proliferative and Apoptotic Landscape of Basal-like Breast Cancer.International journal of molecular sciences · 2019Review
- Clinicopathological Study of Triple Negative Breast Cancers.Journal of clinical and diagnostic research : JCDR · 2016Article
- Article
- Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review.Diagnostic pathology · 2014Review
- Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors.Breast cancer research and treatment · 2014Article
- Clinicopathologic features of triple negative breast cancers: an experience from Pakistan.Diagnostic pathology · 2014Article
- Differences in breast carcinoma immunohistochemical subtypes between immigrant Arab and European women.Diagnostic pathology · 2014Article
- Expression of glucosylceramide synthase in invasive ductal breast cancer may be correlated with high estrogen receptor status and low HER-2 status.Diagnostic pathology · 2014Article
- Lectin histochemistry reveals SNA as a prognostic carbohydrate-dependent probe for invasive ductal carcinoma of the breast: a clinicopathological and immunohistochemical auxiliary tool.International journal of clinical and experimental pathology · 2014Article
- Relation between radiographic BI-RADS scores and triple negativity in patients with ductal carcinomas.International journal of clinical and experimental medicine · 2014Article
- Calretinin expression in high-grade invasive ductal carcinoma of the breast is associated with basal-like subtype and unfavorable prognosis.Human pathology · 2013Article
- Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas.Diagnostic pathology · 2013Article
- Clinico- pathological profile of patients with breast diseases.Diagnostic pathology · 2013Article
- p16 expression correlates with basal-like triple-negative breast carcinoma.Ecancermedicalscience · 2013Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast carcinomas can be classified into five subtypes based on gene expression profiling or immunohistochemical characteristics. Among these subtypes, basal-like breast carcinomas (BLBCs) are one of the most studied group, due to their poor prognosis. The aim of this study was to investigate the prevalance, morphological and immunohistochemical features of BLBCs, in Turkish population.
methodsFive hundred invasive breast carcinomas were reviewed for several morphological features and immunostained for oestrogen and progesterone receptors, c-ERB-B2, cytokeratin5/6, cytokeratin14, vimentin and epidermal growth factor receptor (EGFR). Basal-like breast carcinoma was defined as a triple negative tumor with cytokeratin5/6 and/or EGFR positive.
resultsThe prevalance of BLBC was 9.6%. All medullary carcinomas and 55.6% of metaplastic carcinomas showed basal-like immunophenotype. Patients with BLBC were younger (p=0.04) and had higher-grade tumors (p<0.0001). Morphologic features associated with BLBC included increased mitosis, nuclear pleomorphism, presence of geographic and/or central necrosis, pushing margin of invasion and stromal lymphocytic response (p<0.0001). Presence of prominent nucleoli and vesicular nuclear chromatin were the cytological features correlated with basal-like phenotype (p<0.0001). On multivariate analyses, BLBCs were associated with high mitotic number (p<0.0001), the presence of vesicular chromatin (p=0.004), high tubular grade (p=0.011), lymphocytic response (p=0.031) and the absence of carcinoma insitu (p=0.039). Vimentin was positive in 53.2% of BLBCs, while cytokeratin14 was less frequently expressed (27.7%).
conclusionsBLBCs have some distinctive, but not pathognomonical, morphological features. Paying attention to these features and adding cytokeratin14 and vimentin to the immunohistochemical panel can help the definitive diagnosis of BLBCs. VIRTUAL SLIDE: Http://www.diagnosticpathology.diagnomx.eu/vs/5962175467857400.
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