ArticleBiomedical optics express2012
Automatic and robust calibration of optical detector arrays for biomedical diffuse optical spectroscopy.
Article in Biomedical optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- MRI-Guided Near-Infrared Spectroscopic Tomography (MRg-NIRST) Imaging System With Wearable Breast Optical Interface for Breast Cancer Imaging.IEEE transactions on bio-medical engineering · 2025Article
- Automated data selection method to improve robustness of diffuse optical tomography for breast cancer imaging.Biomedical optics express · 2016Article
- Portable, parallel 9-wavelength near-infrared spectral tomography (NIRST) system for efficient characterization of breast cancer within the clinical oncology infusion suite.Biomedical optics express · 2016Article
- Adaptable near-infrared spectroscopy fiber array for improved coupling to different breast sizes during clinical MRI.Academic radiology · 2014Article
- Anthropomorphic breast phantoms with physiological water, lipid, and hemoglobin content for near-infrared spectral tomography.Journal of biomedical optics · 2014Article
- Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging.Journal of biomedical optics · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The design and testing of a new, fully automated, calibration approach is described. The process was used to calibrate an image-guided diffuse optical spectroscopy system with 16 photomultiplier tubes (PMTs), but can be extended to any large array of optical detectors and associated imaging geometry. The design goals were accomplished by developing a routine for robust automated calibration of the multi-detector array within 45 minutes. Our process was able to characterize individual detectors to a median norm of the residuals of 0.03 V for amplitude and 4.4 degrees in phase and achieved less than 5% variation between all the detectors at the 95% confidence interval for equivalent measurements. Repeatability of the calibrated data from the imaging system was found to be within 0.05 V for amplitude and 0.2 degrees for phase, and was used to evaluate tissue-simulating phantoms in two separate imaging geometries. Spectroscopic imaging of total hemoglobin concentration was recovered to within 5% of the true value in both cases. Future work will focus on streamlining the technology for use in a clinical setting with expectations of achieving accurate quantification of suspicious lesions in the breast.
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Registered trials
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