ArticlePloS one2012
Persistent histamine excitation of glutamatergic preoptic neurons.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Activation of Preoptic Arginine Vasopressin Neurons Induces Hyperthermia in Male Mice.Endocrinology · 2021Article
- Neurotensin induces hypothermia by activating both neuronal neurotensin receptor 1 and astrocytic neurotensin receptor 2 in the median preoptic nucleus.Neuropharmacology · 2020Article
- Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke.Frontiers in cell and developmental biology · 2020Article
- TRPCing around the hypothalamus.Frontiers in neuroendocrinology · 2018Review
- Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin.Neuroscience letters · 2016Article
- Histamine receptor signaling in energy homeostasis.Neuropharmacology · 2016Review
- Central nervous system regulation of brown adipose tissue.Comprehensive Physiology · 2014Review
- Central neural regulation of brown adipose tissue thermogenesis and energy expenditure.Cell metabolism · 2014Review
- Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel.Handbook of experimental pharmacology · 2014Review
- Functional pharmacology of H1 histamine receptors expressed in mouse preoptic/anterior hypothalamic neurons.British journal of pharmacology · 2013Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Thermoregulatory neurons of the median preoptic nucleus (MnPO) represent a target at which histamine modulates body temperature. The mechanism by which histamine excites a population of MnPO neurons is not known. In this study it was found that histamine activated a cationic inward current and increased the intracellular Ca(2+) concentration, actions that had a transient component as well as a sustained one that lasted for tens of minutes after removal of the agonist. The sustained component was blocked by TRPC channel blockers. Single-cell reverse transcription-PCR analysis revealed expression of TRPC1, TRPC5 and TRPC7 subunits in neurons excited by histamine. These studies also established the presence of transcripts for the glutamatergic marker Vglut2 and for the H1 histamine receptor in neurons excited by histamine. Intracellular application of antibodies directed against cytoplasmic sites of the TRPC1 or TRPC5 channel subunits decreased the histamine-induced inward current. The persistent inward current and elevation in intracellular Ca(2+) concentration could be reversed by activating the PKA pathway. This data reveal a novel mechanism by which histamine induces persistent excitation and sustained intracellular Ca(2+) elevation in glutamatergic MnPO neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.