ArticlePloS one2012
Genome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
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- RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation.Molecular autism · 2019Article
- Integrated Analysis of Gene Expression Differences in Twins Discordant for Disease and Binary Phenotypes.Scientific reports · 2018Article
- Personhood status of the human zygote, embryo, fetus.The Linacre quarterly · 2017Article
- Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.Human brain mapping · 2017Article
- Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1.Scientific reports · 2015Article
- Associations between DNA methylation and schizophrenia-related intermediate phenotypes - a gene set enrichment analysis.Progress in neuro-psychopharmacology & biological psychiatry · 2015Article
- Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth.Epigenetics · 2014Article
- Integrated analysis of microarray data of atherosclerotic plaques: modulation of the ubiquitin-proteasome system.PloS one · 2014Article
- Comparison of Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome.PloS one · 2013Article
- DNA methylation profiling of the fibrinogen gene landscape in human cells and during mouse and zebrafish development.PloS one · 2013Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human intelligence, as measured by intelligence quotient (IQ) tests, demonstrates one of the highest heritabilities among human quantitative traits. Nevertheless, studies to identify quantitative trait loci responsible for intelligence face challenges because of the small effect sizes of individual genes. Phenotypically discordant monozygotic (MZ) twins provide a feasible way to minimize the effects of irrelevant genetic and environmental factors, and should yield more interpretable results by finding epigenetic or gene expression differences between twins. Here we conducted array-based genome-wide DNA methylation and gene expression analyses using 17 pairs of healthy MZ twins discordant intelligently. ARHGAP18, related to Rho GTPase, was identified in pair-wise methylation status analysis and validated via direct bisulfite sequencing and quantitative RT-PCR. To perform expression profile analysis, gene set enrichment analysis (GSEA) between the groups of twins with higher IQ and their co-twins revealed up-regulated expression of several ribosome-related genes and DNA replication-related genes in the group with higher IQ. To focus more on individual pairs, we conducted pair-wise GSEA and leading edge analysis, which indicated up-regulated expression of several ion channel-related genes in twins with lower IQ. Our findings implied that these groups of genes may be related to IQ and should shed light on the mechanism underlying human intelligence.
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