ArticlePloS one2012
Sleep deprivation impairs consolidation of cued fear memory in rats.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 75 citations in OpenAlex.
- Morning rapid eye movement sleep naps facilitate broad access to emotional semantic networks.Sleep · 2015Trial
- Light Cycle Phase Effects on Behavioral Responses to Stress Exposure in Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A prolonged stress rat model recapitulates some PTSD-like changes in sleep and neuronal connectivity.Communications biology · 2023Article
- The amygdala mediates the facilitating influence of emotions on memory through multiple interacting mechanisms.Neurobiology of stress · 2023Review
- Total sleep deprivation selectively impairs motor preparation sub-stages in visual search task: Evidence from lateralized readiness potentials.Frontiers in neuroscience · 2023Article
- Compensatory cognition in neurological diseases and aging: A review of animal and human studies.Aging brain · 2023Review
- Electroacupuncture Enhances Cognitive Deficits in a Rat Model of Rapid Eye Movement Sleep Deprivation via Targeting MiR-132.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Use of Actigraphy for a Rat Behavioural Sleep Study.Clocks & sleep · 2021Article
- Locus Coeruleus Acid-Sensing Ion Channels Modulate Sleep-Wakefulness and State Transition from NREM to REM Sleep in the Rat.Neuroscience bulletin · 2021Article
- Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction.Animal cells and systems · 2021Article
- Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation.Clocks & sleep · 2020Article
- Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance.Neural regeneration research · 2020Article
- Dietary polyphenols promote resilience against sleep deprivation-induced cognitive impairment by activating protein translation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Fear memory consolidation in sleep requires protein kinase A.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Memory creation and modification: Enhancing the treatment of psychological disorders.The American psychologist · 2018Review
- Training on an Appetitive (Delay)-Conditioning Task Enhances Oscillatory Waves During Sleep in the Cortical and Amygdalar Network.Frontiers in behavioral neuroscience · 2018Article
- The basolateral amygdala can mediate the effects of fear memory on sleep independently of fear behavior and the peripheral stress response.Neurobiology of learning and memory · 2017Article
- Short-Term Total Sleep-Deprivation Impairs Contextual Fear Memory, and Contextual Fear-Conditioning Reduces REM Sleep in Moderately Anxious Swiss Mice.Frontiers in behavioral neuroscience · 2017Article
- Circadian Rhythms in Fear Conditioning: An Overview of Behavioral, Brain System, and Molecular Interactions.Neural plasticity · 2017Review
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-learning sleep facilitates negative memory consolidation and also helps preserve it over several years. It is believed, therefore, that sleep deprivation may help prevent consolidation of fearful memory. Its effect, however, on consolidation of negative/frightening memories is not known. Cued fear-conditioning (CuFC) is a widely used model to understand the neural basis of negative memory associated with anxiety disorders. In this study, we first determined the suitable circadian timing for consolidation of CuFC memory and changes in sleep architecture after CuFC. Thereafter, we studied the effect of sleep deprivation on CuFC memory consolidation. Three sets of experiments were performed in male Wistar rat (n=51). In experiment-I, animals were conditioned to cued-fear by presenting ten tone-shock paired stimuli during lights-on (7 AM) (n=9) and lights-off (7 PM) (n=9) periods. In experiment-II, animals were prepared for polysomnographic recording (n=8) and changes in sleep architecture after CuFC was determined. Further in experiment-III, animals were cued fear-conditioned during the lights-off period and were randomly divided into four groups: Sleep-Deprived (SD) (n=9), Non-Sleep Deprived (NSD) (n=9), Stress Control (SC) (n=9) and Tone Control (n=7). Percent freezing amount, a hallmark of fear, was compared statistically in these groups. Rats trained during the lights-off period exhibited significantly more freezing compared to lights-on period. In CuFC trained animals, total sleep amount did not change, however, REM sleep decreased significantly. Further, out of total sleep time, animals spent proportionately more time in NREM sleep. Nevertheless, SD animals exhibited significantly less freezing compared to NSD and SC groups. These data suggest that sleep plays an important role in the consolidation of cued fear-conditioned memory.
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