ArticlePloS one2012
Genome-wide identification and analysis of MAPK and MAPKK gene families in Brachypodium distachyon.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 146 citations in OpenAlex.
- Molecular mechanisms and evolutionary adaptations of transporters for photosynthates and specialized metabolites in plants.Plant cell reports · 2026Review
- Mitogen-activated protein kinase (MAPK) gene family identification reveals GhMPK10-mediated regulation of abiotic stress tolerance through protein kinase signaling cascades in cotton.BMC plant biology · 2025Article
- Genome-wide identification and molecular characterization of the MAPK family members in sand pear (Pyrus pyrifolia).BMC genomics · 2025Article
- Identification of MAPK Genes inInternational journal of molecular sciences · 2024Article
- Genome-Wide Identification of MKK Gene Family and Response to Hormone and Abiotic Stress in Rice.Plants (Basel, Switzerland) · 2024Article
- Genome-wide identification, classification and expression analysis of the heat shock transcription factor family in Garlic (Allium sativum L.).BMC plant biology · 2024Article
- Genome-wide identification of MAPK family in papaya (Carica papaya) and their involvement in fruit postharvest ripening.BMC plant biology · 2024Article
- Identification and expression analysis of MAPK cascade gene family in foxtail millet (Plant signaling & behavior · 2023Article
- The effect of a-Lipoic acid (ALA) on oxidative stress, inflammation, and apoptosis in high glucose-induced human corneal epithelial cells.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Impact of high atmospheric carbon dioxide on the biotic stress response of the model cereal speciesFrontiers in plant science · 2023Article
- Genome-Wide Identification and Expression Analysis of MAPK Gene Family in Lettuce (International journal of molecular sciences · 2022Article
- Genome-wide identification and characterization of the MAPKKK, MKK, and MPK families in Chinese elite maize inbred line Huangzaosi.The plant genome · 2022Article
- Ectopic Expression of OsJAZs Alters Plant Defense and Development.International journal of molecular sciences · 2022Article
- Genome-wide identification of MAPK gene family members in Fagopyrum tataricum and their expression during development and stress responses.BMC genomics · 2022Article
- Genome-Wide Identification of MAPK, MAPKK, and MAPKKK Gene Families inFrontiers in genetics · 2022Article
- Mitogen-Activated Protein Kinase Expression Profiling Revealed Its Role in Regulating Stress Responses in Potato (Plants (Basel, Switzerland) · 2021Article
- Genome-Wide Identification and Analysis ofInternational journal of molecular sciences · 2021Article
- A phylogenetic study of the members of the MAPK and MEK families across Viridiplantae.PloS one · 2021Article
- Identification, Characterization, and Expression Profile Analysis of theFrontiers in plant science · 2021Article
- Comparative analysis ofPeerJ · 2021Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MAPK cascades are universal signal transduction modules and play important roles in plant growth, development and in response to a variety of biotic and abiotic stresses. Although MAPKs and MAPKKs have been systematically investigated in several plant species including Arabidopsis, rice and poplar, no systematic analysis has been conducted in the emerging monocot model plant Brachypodium distachyon. In the present study, a total of 16 MAPK genes and 12 MAPKK genes were identified from B. distachyon. An analysis of the genomic evolution showed that both tandem and segment duplications contributed significantly to the expansion of MAPK and MAPKK families. Evolutionary relationships within subfamilies were supported by exon-intron organizations and the architectures of conserved protein motifs. Synteny analysis between B. distachyon and the other two plant species of rice and Arabidopsis showed that only one homolog of B. distachyon MAPKs was found in the corresponding syntenic blocks of Arabidopsis, while 13 homologs of B. distachyon MAPKs and MAPKKs were found in that of rice, which was consistent with the speciation process of the three species. In addition, several interactive protein pairs between the two families in B. distachyon were found through yeast two hybrid assay, whereas their orthologs of a pair in Arabidopsis and other plant species were not found to interact with each other. Finally, expression studies of closely related family members among B. distachyon, Arabidopsis and rice showed that even recently duplicated representatives may fulfill different functions and be involved in different signal pathways. Taken together, our data would provide a foundation for evolutionary and functional characterization of MAPK and MAPKK gene families in B. distachyon and other plant species to unravel their biological roles.
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