Trial reportPloS one2012
Treating and preventing influenza in aged care facilities: a cluster randomised controlled trial.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review.Journal of public health (Oxford, England) · 2024Pooled it
- Pooled it
- Medications and Prescribing Patterns as Factors Associated with Hospitalizations from Long-Term Care Facilities: A Systematic Review.Drugs & aging · 2018Pooled it
- Influenza outbreak control practices and the effectiveness of interventions in long-term care facilities: a systematic review.Influenza and other respiratory viruses · 2014Pooled it
- Effectiveness of a theory-informed intervention to increase care home staff influenza vaccination rates: a cluster randomised controlled trial.Journal of public health (Oxford, England) · 2025Trial
- Managing acute respiratory infection outbreaks in care homes: A cross-sectional study of public health response across South East England.Journal of infection prevention · 2026Article
- Prompt and Intensive Antiviral Chemoprophylaxis in Nursing Home Influenza Outbreaks.JAMA internal medicine · 2026Article
- AMMI Canada 2023 update on influenza: Management and emerging issues.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2023Article
- Review
- Epidemiology of 2017 influenza outbreaks in nine Australian Aged care facilities.Influenza and other respiratory viruses · 2021Article
- Effectiveness of Oseltamivir Prophylaxis in Influenza Outbreaks in Residential Aged Care.Journal of epidemiology and global health · 2020Article
- Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Molecular characterization of a nosocomial outbreak of influenza B virus in an acute care hospital setting.The Journal of hospital infection · 2019Article
- Burden, effectiveness and safety of influenza vaccines in elderly, paediatric and pregnant populations.Therapeutic advances in vaccines and immunotherapy · 2019Review
- The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital.Internal medicine (Tokyo, Japan) · 2018Article
- Influenza.Annals of internal medicine · 2017Review
- Article
- Oseltamivir prophylaxis in controlling influenza outbreak in nursing homes: a comparison between three different approaches.Infection · 2015Article
- Effectiveness of post-exposition prophylaxis with oseltamivir in nursing homes: a randomised controlled trial over four seasons.Emerging themes in epidemiology · 2014Article
- Effect of antiviral prophylaxis on influenza outbreaks in aged care facilities in three local health districts in New South Wales, Australia, 2014.Western Pacific surveillance and response journal : WPSARArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfluenza is an important cause of morbidity and mortality for frail older people. Whilst the antiviral drug oseltamivir (a neuraminidase inhibitor) is approved for treatment and prophylaxis of influenza during outbreaks, there have been no trials comparing treatment only (T) versus treatment and prophylaxis (T&P) in Aged Care Facilities (ACFs). Our objective was to compare a policy of T versus T&P for influenza outbreaks in ACFs. METHODS AND
findingsWe performed a cluster randomised controlled trial in 16 ACFs, that followed a policy of either "T"-oseltamivir treatment (75 mg twice a day for 5 days)-or "T&P"-treatment and prophylaxis (75 mg once a day for 10 days) for influenza outbreaks over three years, in addition to enhanced surveillance. The primary outcome measure was the attack rate of influenza. Secondary outcomes measures were deaths, hospitalisation, pneumonia and adverse events. Laboratory testing was performed to identify the viral cause of influenza-like illness (ILI) outbreaks. The study period 30 June 2006 to 23 December 2008 included three southern hemisphere winters. During that time, influenza was confirmed as the cause of nine of the 23 ILI outbreaks that occurred amongst the 16 ACFs. The policy of T&P resulted in a significant reduction in the influenza attack rate amongst residents: 93/255 (36%) in residents in T facilities versus 91/397 (23%) in T&P facilities (p=0.002). We observed a non-significant reduction in staff: 46/216 (21%) in T facilities versus 47/350 (13%) in T&P facilities (p=0.5). There was a significant reduction in mean duration of outbreaks (T=24 days, T&P=11 days, p=0.04). Deaths, hospitalisations and pneumonia were non-significantly reduced in the T&P allocated facilities. Drug adverse events were common but tolerated.
conclusionOur trial lacked power but these results provide some support for a policy of "treatment and prophylaxis" with oseltamivir in controlling influenza outbreaks in ACFs.
trial registration[corrected] Australian Clinical Trials Registry ACTRN12606000278538.
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