ArticlePloS one2012
Profound olfactory dysfunction in myasthenia gravis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Non-Motor Symptoms in Myasthenia Gravis Patients: Evaluation of Auditory and Olfactory Functions.Noro psikiyatri arsivi · 2026Article
- The overlooked side of myasthenia gravis: the non-motor manifestations-a comprehensive review.Journal of neurology · 2025Review
- Olfactory Dysfunction in Patients With Acetylcholine-Receptor-Antibody-Positive Myasthenia Gravis.Journal of clinical neurology (Seoul, Korea) · 2025Article
- Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older.NPJ Parkinson's disease · 2025Article
- Beyond the Surface: Investigating the Potential Mechanisms of Non-Motor Symptoms in Myasthenia Gravis.European journal of neurology · 2025Review
- Odors as cognitive constructs: history of odor classification and attempts to map odor percepts to physical and chemical parameters.Chemical senses · 2025Review
- Evaluation of nonmotor symptoms in myasthenia gravis patients.Turkish journal of medical sciences · 2025Article
- Inflammation and olfactory loss are associated with at least 139 medical conditions.Frontiers in molecular neuroscience · 2024Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression.Frontiers in neuroscience · 2022Article
- Myasthenia Gravis-An Analysis of Multimodal Evoked Potentials.Brain sciences · 2021Article
- Evaluation of Olfactory Bulb Volumes in Patients With Rheumatoid Arthritis: A Retrospective Study.Archives of rheumatology · 2019Article
- Pain, Headache, and Other Non-motor Symptoms in Myasthenia Gravis.Current pain and headache reports · 2018Review
- Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature.Frontiers in neurology · 2018Article
- Decreased olfactory bulb volumes in patients with fibromyalgia syndrome.Clinical rheumatology · 2017Article
- Article
- "Unclassical" Combination of Smell Dysfunction, Altered Abdominal Nociception and Human Hypertension Associated "Classical" Adrenal-Augmentation.Journal of medical cases · 2015Article
- Olfactory dysfunction and its measurement in the clinic.World journal of otorhinolaryngology - head and neck surgery · 2015Review
- Olfactory dysfunction in Parkinson's disease: Positive effect of cigarette smoking.Movement disorders : official journal of the Movement Disorder Society · 2015Article
- Olfactory impairment in patients with the fibromyalgia syndrome and systemic sclerosis.Immunologic research · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we demonstrate that myasthenia gravis, an autoimmune disease strongly identified with deficient acetylcholine receptor transmission at the post-synaptic neuromuscular junction, is accompanied by a profound loss of olfactory function. Twenty-seven MG patients, 27 matched healthy controls, and 11 patients with polymiositis, a disease with peripheral neuromuscular symptoms analogous to myasthenia gravis with no known central nervous system involvement, were tested. All were administered the University of Pennsylvania Smell Identification Test (UPSIT) and the Picture Identification Test (PIT), a test analogous in content and form to the UPSIT designed to control for non-olfactory cognitive confounds. The UPSIT scores of the myasthenia gravis patients were markedly lower than those of the age- and sex-matched normal controls [respective means (SDs) =20.15 (6.40) & 35.67 (4.95); p<0.0001], as well as those of the polymiositis patients who scored slightly below the normal range [33.30 (1.42); p<0.0001]. The latter finding, along with direct monitoring of the inhalation of the patients during testing, implies that the MG-related olfactory deficit is unlikely due to difficulties sniffing, per se. All PIT scores were within or near the normal range, although subtle deficits were apparent in both the MG and PM patients, conceivably reflecting influences of mild cognitive impairment. No relationships between performance on the UPSIT and thymectomy, time since diagnosis, type of treatment regimen, or the presence or absence of serum anti-nicotinic or muscarinic antibodies were apparent. Our findings suggest that MG influences olfactory function to the same degree as observed in a number of neurodegenerative diseases in which central nervous system cholinergic dysfunction has been documented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.