ArticlePloS one2012
Genome analysis of a highly virulent serotype 1 strain of Streptococcus pneumoniae from West Africa.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The epidemiology of infectious meningitis in Ghana: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Trial
- Subtractive genomics and drug repurposing strategies for targetingFrontiers in microbiology · 2025Article
- Molecular epidemiology of Streptococcus pneumoniae isolates causing invasive and noninvasive infection in Ethiopia.Scientific reports · 2024Article
- Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA.Genome medicine · 2022Article
- Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms.Trends in microbiology · 2022Review
- Phylogeography and resistome of pneumococcal meningitis in West Africa before and after vaccine introduction.Microbial genomics · 2021Article
- Article
- Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism.Communications biology · 2020Article
- Lysogeny inMicroorganisms · 2020Review
- Methylation Warfare: Interaction of Pneumococcal Bacteriophages with Their Host.Journal of bacteriology · 2019Article
- Genomics and Genetics ofMicrobiology spectrum · 2019Review
- Micro-evolution of three Streptococcus species: selection, antigenic variation, and horizontal gene inflow.BMC evolutionary biology · 2019Article
- An outbreak of pneumococcal meningitis among older children (≥5 years) and adults after the implementation of an infant vaccination programme with the 13-valent pneumococcal conjugate vaccine in Ghana.BMC infectious diseases · 2016Article
- Region-specific diversification of the highly virulent serotype 1Microbial genomics · 2015Article
- Frequency of Streptococcus pneumoniae infection in patients with suspected meningitis in Imam Reza Hospital of Kermanshah in the west of Iran.Iranian journal of microbiology · 2015Article
- Article
- Non-typeable pneumococci circulating in Portugal are of cps type NCC2 and have genomic features typical of encapsulated isolates.BMC genomics · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and bacteremia, estimated to cause 2 million deaths annually. The majority of pneumococcal mortality occurs in developing countries, with serotype 1 a leading cause in these areas. To begin to better understand the larger impact that serotype 1 strains have in developing countries, we characterized virulence and genetic content of PNI0373, a serotype 1 strain from a diseased patient in The Gambia. PNI0373 and another African serotype 1 strain showed high virulence in a mouse intraperitoneal challenge model, with 20% survival at a dose of 1 cfu. The PNI0373 genome sequence was similar in structure to other pneumococci, with the exception of a 100 kb inversion. PNI0373 showed only 15 lineage specific CDS when compared to the pan-genome of pneumococcus. However analysis of non-core orthologs of pneumococcal genomes, showed serotype 1 strains to be closely related. Three regions were found to be serotype 1 associated and likely products of horizontal gene transfer. A detailed inventory of known virulence factors showed that some functions associated with colonization were absent, consistent with the observation that carriage of this highly virulent serotype is unusual. The African serotype 1 strains thus appear to be closely related to each other and different from other pneumococci despite similar genetic content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.