ArticleEvidence-based complementary and alternative medicine : eCAM2012
In vitro screening of medicinal plants used in Mexico as antidiabetics with glucosidase and lipase inhibitory activities.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
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- Solvent Fractionation and LC-MS Profiling, Antioxidant Properties, and α-Glucosidase Inhibitory Activity ofMolecules (Basel, Switzerland) · 2025Article
- In Silico Analysis: Anti-Inflammatory and α-Glucosidase Inhibitory Activity of New α-Methylene-γ-Lactams.Molecules (Basel, Switzerland) · 2024Article
- A comprehensive review on ecology, life cycle and use of Tecoma stans (bignoneaceae).Botanical studies · 2024Review
- Metabolic Disorder Therapeutics and their Effects on Memory.CNS & neurological disorders drug targets · 2024Review
- Wound Healing and Acute Dermal Toxicity Studies ofJournal of tropical medicine · 2024Article
- Digestion-Related Enzyme Inhibition Potential of Selected Mexican Medicinal Plants (Foods (Basel, Switzerland) · 2023Article
- Chemical Characterization, Antilipidemic Effect and Anti-Obesity Activity ofPlants (Basel, Switzerland) · 2023Article
- Evidence-Based Anti-Diabetic Properties of Plant from the Occitan Valleys of the Piedmont Alps.Pharmaceutics · 2022Review
- Carbon Source Influences Antioxidant, Antiglycemic, and Antilipidemic Activities ofMarine drugs · 2022Article
- Effect ofPlants (Basel, Switzerland) · 2022Article
- Screening natural product extracts for potential enzyme inhibitors: protocols, and the standardisation of the usage of blanks in α-amylase, α-glucosidase and lipase assays.Plant methods · 2021Article
- Phytochemical properties of black tea (Journal of food science and technology · 2020Article
- Antihyperglycemic Effects ofMolecules (Basel, Switzerland) · 2020Article
- Untargeted Metabolomic Profiling, Multivariate Analysis and Biological Evaluation of the True Mangrove (Antioxidants (Basel, Switzerland) · 2019Article
- Antidiabetic Potential of Medicinal Plants and Their Active Components.Biomolecules · 2019Review
- Identification of Digestive Enzyme Inhibitors fromEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Effects of Aphloia theiformis on key enzymes related to diabetes mellitus.Pharmaceutical biology · 2017Article
- Effects of Passiflora nitida Kunth leaf extract on digestive enzymes and high caloric diet in rats.Journal of natural medicines · 2014Article
- In silico molecular docking and in vitro antidiabetic studies of dihydropyrimido[4,5-a]acridin-2-amines.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work shows the inhibitory effect on glucosidase and lipase enzymes of 23 medicinal plants described as traditional treatments for diabetes in several Mexican sources. Hydroalcoholic extracts of selected plants were evaluated at 1 mg/mL for glucosidase and 0.25 mg/mL for lipase inhibitory activities, respectively. Camellia sinensis, acarbose, and orlistat were used as positive controls. Dose-response curves were done with the most active species. Sixty percent of all tested extracts inhibited more than 25% of α-glucosidase activity. C. sinensis displayed an inhibition of 85% (IC(50) = 299 μg/mL), while Ludwigia octovalvis and Iostephane heterophylla showed the highest inhibition (82.7 %, IC(50) = 202 μg/mL and 60.6%, CI(50) = 509 μg/mL, resp.). With respect to lipase activity, L. octovalvis and Tecoma stans were the most inhibiting treatments (31.4%, IC(50) = 288 μg/mL; 27.2%, IC(50) = 320 μg/mL), while C. sinensis displayed 45% inhibition (IC(50) = 310 μg/mL). These results indicate that a high proportion of plants used in Mexico as treatment for diabetes displays significant inhibition of these digestive enzymes.
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Registered trials
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