ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2013
The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 121 citations in OpenAlex.
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- A new target of radiotherapy combined with immunotherapy: regulatory T cells.Frontiers in immunology · 2023Review
- A review on lymphocyte radiosensitivity and its impact on radiotherapy.Frontiers in oncology · 2023Review
- Dual effects of radiotherapy on tumor microenvironment and its contribution towards the development of resistance to immunotherapy in gastrointestinal and thoracic cancers.Frontiers in cell and developmental biology · 2023Review
- The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers.Cancers · 2022Review
- Antitumor efficacy ofJournal for immunotherapy of cancer · 2022Article
- Using Radiation Therapy to Prime and Propagate an Anti-tumor Immune Response Against Brain Tumors.Neuromolecular medicine · 2022Review
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- Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade.Science translational medicine · 2021Article
- Low dose ionizing radiation effects on the immune system.Environment international · 2021Review
- Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide.Cancer immunology, immunotherapy : CII · 2021Article
- Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?Journal for immunotherapy of cancer · 2021Review
- Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review.Frontiers in oncology · 2021Review
- The Promise of Combining Radiation Therapy With Immunotherapy.International journal of radiation oncology, biology, physics · 2020Review
- The interplay between cancer associated fibroblasts and immune cells in the context of radiation therapy.Molecular carcinogenesis · 2020Review
- The resveratrol analogue, HS‑1793, enhances the effects of radiation therapy through the induction of anti‑tumor immunity in mammary tumor growth.International journal of oncology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRadiotherapy affects antitumor immune responses; therefore, it is important to study radiation effects on various compartments of the immune system. Here we report radiation effects on the homeostasis and function of regulatory T (Treg) cells, which are important in down-regulating antitumor immune responses.
methodsC57Bl/6 mice were irradiated with 2 Gy and alterations in splenic lymphocyte fractions analyzed at different intervals.
resultsTotal CD4+ numbers showed stronger decrease after irradiation than CD4+Foxp3+ Tregs. Tregs were less prone to radiation-induced apoptosis than CD4+Foxp3- T cells. The ratio of CD4+Foxp3- and CD4+Foxp3+ fractions within the proliferating CD4+ pool progressively changed from 74:26 in control animals to 59:41 eleven days after irradiation, demonstrating a more dynamic increase in the proliferation and regeneration of the Treg pool. The CD4+Foxp3+ fraction expressing cell-surface CTLA4, an antigen associated with Treg cell activation increased from 5.3 % in unirradiated mice to 10.5 % three days after irradiation. The expression of IL-10 mRNA was moderately upregulated, while TGF-β expression was not affected. On the other hand, irradiation reduced Treg capacity to suppress effector T cell proliferation by 2.5-fold.
conclusionTregs are more radioresistant, less prone to radiation-induced apoptosis, and have faster repopulation kinetics than CD4+Foxp3- cells, but irradiated Tregs are functionally compromised, having a reduced suppressive capacity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.