ArticleGenetics and molecular research : GMR2012
Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia.
Article in Genetics and molecular research : GMR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Small RNAs and tooth development: The role of microRNAs in tooth agenesis and impaction.Journal of dental sciences · 2024Article
- [Detection and functional analysis of BMP2 gene mutation in patients with tooth agenesis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- Mutation analysis by direct and whole exome sequencing in familial and sporadic tooth agenesis.International journal of molecular medicine · 2016Article
- Establishment of Immortalized BMP2/4 Double Knock-Out Osteoblastic Cells Is Essential for Study of Osteoblast Growth, Differentiation, and Osteogenesis.Journal of cellular physiology · 2016Article
- Genetic Variants of BMP2 and Their Association with the Risk of Non-Syndromic Tooth Agenesis.PloS one · 2016Article
- Single Nucleotide Polymorphisms in Runt-related Transcription Factor 2 and Bone Morphogenetic Protein 2 Impact on Their Maxillary and Mandibular Gene Expression in Different Craniofacial Patterns - A Comparative Study.Annals of maxillofacial surgeryArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Both BMP2 and BMP4 are involved in tooth development. We examined phenotypes and BMP2 and BMP4 gene variations in two Mexican oligodontia families. Physical and oral examinations and panoramic radiographs were performed on affected and unaffected members in these two families. The affected members lacked six or more teeth. DNA sequencing was performed to detect BMP2 and BMP4 gene variations. Three single nucleotide polymorphisms (SNPs) in BMP2 and BMP4 genes were identified in the two families, including one synonymous and two missense SNPs: BMP2 c261A>G, pS87S, BMP2 c570A>T, pR190S, and BMP4 c455T>C, pV152A. Among the six affected patients, 67% carried "GG" or "AG" genotype in BMP2 c261A>G and four were "TT" or "AT" genotype in BMP2 c570A>T (pR190S). Polymorphism of BMP4 c455T>C resulted in amino acid changes of Val/Ala (pV152A). BMP2 c261A>G and BMP4 c455T>C affect mRNA stability. This was the first time that BMP2 and BMP4 SNPs were observed in Mexican oligodontia families.
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