Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2012
Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular mechanism of Alzheimer's disease using integrated multi-omics.Frontiers in aging neuroscience · 2026Review
- Association of neuroticism with incident dementia and cognitive function: 26-year follow-up of EPIC-Norfolk study.Age and ageing · 2025Article
- Association of neuroticism with incident dementia, neuroimaging outcomes, and cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Examining the relationship between anxiety and regional brain volumes in the National Alzheimer's Coordinating Center uniform, imaging, and biomarker datasets.Cerebral circulation - cognition and behavior · 2024Article
- Loneliness and risk of all-cause, Alzheimer's, vascular, and frontotemporal dementia: a prospective study of 492,322 individuals over 15 years.International psychogeriatrics · 2023Article
- Subjective Cognitive Decline: Is a Resilient Personality Protective Against Progression to Objective Cognitive Impairment? Findings from Two Community-Based Cohort Studies.Journal of Alzheimer's disease : JAD · 2022Article
- CAG Repeats Within the Non-pathological Range in the HTT Gene Influence Personality Traits in Patients With Subjective Cognitive Decline: A 13-Year Follow-Up Study.Frontiers in psychiatry · 2022Article
- The Relation Between Personality and Biomarkers in Sensitivity and Conversion to Alzheimer-Type Dementia.Journal of the International Neuropsychological Society : JINS · 2020Article
- Personality and Incident Alzheimer's Disease: Theory, Evidence, and Future Directions.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020Review
- Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions.Frontiers in aging neuroscience · 2019Review
- Personality and Alzheimer's disease: An integrative review.Personality disorders · 2019Review
- Sociodemographic, Medical, and Psychosocial Factors Associated With Supportive Care Needs in Adults Diagnosed With Uveal Melanoma.JAMA ophthalmology · 2018Article
- Facets of Conscientiousness and risk of dementia.Psychological medicine · 2018Article
- Article
- Moderating risk of Alzheimer's disease through the use of anxiolytic agents.International journal of geriatric psychiatry · 2017Article
- Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer's disease pathology modulates cognitive performance.Alzheimer's research & therapy · 2017Article
- Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults.International journal of geriatric psychiatry · 2016Article
- Subjective Cognitive Complaints, Personality and Brain Amyloid-beta in Cognitively Normal Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015Observational
- Common genetic variation of the APOE gene and personality.BMC neuroscience · 2014Article
- The relationship between personality traits and Alzheimer's disease: a narrative review.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesWe tested the hypothesis that neuroticism moderates the association between APOE (apolipoprotein E) genotype and two major outcomes, cognitive function and Alzheimer disease. We also explored whether other personality dimensions (extraversion, openness to experience, agreeableness, and conscientiousness) moderate the associations of APOE with these outcomes.
designPrimary analyses of existing randomized clinical trial data. SAMPLE: Six-hundred two older adults (mean age of 78 years at baseline). MEASUREMENTS: APOE genotype, the NEO-Five Factor Inventory, the Alzheimer's Disease Assessment Scale-Cognitive: measured every 6 months for 6.5 years) and relevant covariates.
resultsFully adjusted multivariate analyses showed that the association between the presence of APOE [Latin Small Letter Open E]-4 allele(s) and both outcomes was evident among individuals with high levels of neuroticism and extraversion but not among persons with low levels of these traits.
conclusionsPhenotypic personality dimensions, primarily neuroticism and extraversion, moderate the relationship between APOE [Latin Small Letter Open E]-4 genotype and cognitive outcomes among older adults. Future research is needed to elucidate the physiological processes involved in these particular phenotype-genotype interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.