SynthesisInternational archives of occupational and environmental health2013
Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium.
Synthesis in International archives of occupational and environmental health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Aircraft Noise and the Risk of Stroke.Deutsches Arzteblatt international · 2019Pooled it
- Pooled it
- Molecular signatures under hexavalent chromium, particulate matter 2.5, and cigarette smoking exposures.Discover oncology · 2025Article
- Article
- The OCCHLTH Mnemonic-Construction and Content of a Tool for Increasing Awareness of Occupational Illness and Injury.Journal of occupational and environmental medicine · 2024Review
- Adverse Human Health Effects of Chromium by Exposure Route: A Comprehensive Review Based on Toxicogenomic Approach.International journal of molecular sciences · 2023Review
- Chromium (VI)-induced ALDH1A1/EGF axis promotes lung cancer progression.Clinical and translational medicine · 2022Article
- MicroRNA-Gene Interactions Impacted by Toxic Metal(oid)s during EMT and Carcinogenesis.Cancers · 2022Review
- On the Determination of Cr(VI) in Cr(III)-Rich Particulates: From the Failure of Official Methods to the Development of an Alternative Protocol.International journal of environmental research and public health · 2022Article
- Health hazards of hexavalent chromium (Cr (VI)) and its microbial reduction.Bioengineered · 2022Review
- Medical Device Industry Approaches for Addressing Sources of Failing Cytotoxicity Scores.Biomedical instrumentation & technology · 2021Article
- A Novel Transcriptome Integrated Network Approach Identifies the Key Driver lncRNA Involved in Cell Cycle With Chromium (VI)-Treated BEAS-2B Cells.Frontiers in genetics · 2020Article
- Exploring the statistical uncertainty in acceptable exposure limit values for hexavalent chromium exposure.Journal of exposure science & environmental epidemiology · 2018Article
- Review of carcinogenicity of hexavalent chrome and proposal of revising approval standards for an occupational cancers in Korea.Annals of occupational and environmental medicine · 2018Article
- Quercetin inhibits Cr(VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway.Oncotarget · 2017Article
- Carcinogenicity of chromium and chemoprevention: a brief update.OncoTargets and therapy · 2017Review
- Feasibility of Biological Effective Monitoring of Chrome Electroplaters to Chromium through Analysis of Serum Malondialdehyde.The international journal of occupational and environmental medicine · 2016Article
- Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling.Oncotarget · 2016Article
- Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the exposure-risk relationship for occupational chromium (VI) exposure and lung cancer in order to establish exposure limits.
methodsWe systematically searched for studies reporting on occupational Cr(VI) exposure and cancers of the respiratory tract. To be included, studies needed to provide data for more than one level of occupational Cr(VI) exposure, adequately consider the confounder smoking and be of adequate methodological quality. Because direct genotoxicity was considered the predominant mechanism of carcinogenesis of Cr(VI), linear models were applied in order to fit risk data. Relative risks were calculated based on these linear regression models and then used to estimate excess absolute risks.
resultsFive studies of two cohorts of chromium production workers in Baltimore, Maryland, and Painesville, Ohio, were included. Based on different estimates for the exposure effect, the absolute excess risk was found to be "acceptable" (less than 4 per 10,000 according to the German Committee on Hazardous Substances, "AGS") at a Cr(VI) concentration of 0.1 μg/m(3), and became "intolerable" (more than 4 per 1,000) beyond a Cr(VI) concentration of 1 μg/m(3).
conclusionOccupational exposure limits for Cr(VI) based on excess absolute risks can be derived from published data identified by a systematic literature review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.