ArticleAmerican journal of epidemiology2012
Lifestyle factors and their combined impact on the risk of colorectal polyps.
Article in American journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04552405 (Preventive Anti-inflammatory Diet to Reduce Gastro-intestinal Inflammation in FAP Patients), which is not on this map. Cited by 49 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventive Anti-inflammatory Diet to Reduce Gastro-intestinal Inflammation in FAP Patients: a Prospective Pilot Study
Who cites it
49 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Modifiable lifestyle and metabolic risk factors for colorectal polyps: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Association between dietary factors and colorectal serrated polyps: a systematic review and meta-analysis.Frontiers in nutrition · 2023Pooled it
- Combined Effect of Healthy Lifestyle Factors and Risks of Colorectal Adenoma, Colorectal Cancer, and Colorectal Cancer Mortality: Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas.The Cochrane database of systematic reviews · 2017Pooled it
- Smoking-associated risks of conventional adenomas and serrated polyps in the colorectum.Cancer causes & control : CCC · 2015Pooled it
- A prospective, multicenter pilot study to investigate the feasibility and safety of a 1-year controlled exercise training after adjuvant chemotherapy in colorectal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Trial
- Observational
- Ideal cardiovascular health (CVH) behaviour is associated with a lower presence of colorectal adenomas and serrated polyps.BMC public health · 2025Article
- Machine Learning-Based Prediction of Histopathological Classification in Colorectal Polyps.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Causal association between body mass index and risk of colon polyps: A Mendelian randomization study.Medicine · 2025Article
- Article
- The role of BMI, serum lipid profile molecules and their derivative indexes in colorectal polyps.Advances in laboratory medicine · 2024Article
- Derivation and validation of a nomogram incorporating modifiable lifestyle factors to predict development of colorectal adenomas after negative index colonoscopy.Scientific reports · 2024Article
- Case-control study: Unveiling human polyomaviruses and papillomavirus in Egyptian colorectal cancer patients.PloS one · 2024Article
- Acceleration of benzo(a)pyrene-induced colon carcinogenesis by Western diet in a rat model of colon cancer.Current research in toxicology · 2024Article
- Metabolic risk factors link unhealthy lifestyles to the risk of colorectal polyps in China.Preventive medicine reports · 2023Article
- Association between Sleep Duration and Colorectal Adenomas: Findings from a Case-Control Study in Vietnam.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Associations of Evolutionary-Concordance Diet and Lifestyle Pattern Scores with Incident, Sporadic Colorectal Adenoma in a Pooled Case-Control Study.Nutrition and cancer · 2022Article
- Anesthesia Assistance in Colonoscopy: Impact on Quality Indicators.Frontiers in medicine · 2022Article
- Association between body mass index and colorectal adenomas: Findings from a case-control study in Vietnam.International journal of cancer · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Understanding patterns of shared and type-specific etiologies for colorectal polyps may provide insights into colorectal carcinogenesis. The authors present the first systematic comparison of risk factors by colorectal polyp type in a large colonoscopy-based case-control study of 3,764 polyp-free controls and 2,543 polyp patients, including 1,444 cases with adenomas only, 662 cases with hyperplastic polyps (HPPs) only, and 437 cases with synchronous HPPs and adenomas. Surveys were completed to obtain information on usual dietary intake and other lifestyle factors. Six lifestyle factors, including cigarette smoking, obesity, no regular use of nonsteroidal anti-inflammatory drugs, high intake of red meat, low intake of fiber, and low intake of calcium, were found to be independently associated with the risk of polyps. The risk of polyps increased progressively with an increasing number of adverse lifestyle factors. Compared with participants with no or only 1 risk factor, odds ratios for those with 5 to 6 risk factors were 2.72 (95% confidence interval: 1.94, 3.79) for adenoma only, 4.12 (95% confidence interval: 2.78, 6.09) for HPPs only, and 9.03 (95% confidence interval: 5.69, 14.34) for synchronous HPPs and adenomas. This study provides strong evidence that lifestyle modification is important for the prevention of colorectal polyps, especially advanced and multiple adenomas, which are established precursors of colorectal cancer.
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Registered trials
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