ArticleDevelopmental cell2012
The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation.
Article in Developmental cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Proteostasis failure and mitochondrial dysfunction contribute to chromosomal instability-induced microcephaly.Nature communications · 2026Article
- From the Making of a Neural Lineage to the Making of a Tumor: Lessons from the "Simple" Drosophila Brain.Advances in experimental medicine and biology · 2025Review
- scRNA-seq data from the larval Drosophila ventral cord provides a resource for studying motor systems function and development.Developmental cell · 2024Article
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- A nonneural miRNA cluster mediates hearing via repression of two neural targets.Genes & development · 2023Article
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- Adult Neurogenesis in theInternational journal of molecular sciences · 2020Review
- Homeostatic maintenance and age-related functional decline in the Drosophila ear.Scientific reports · 2020Article
- Distinct gene-selective roles for a network of core promoter factors inBiology open · 2019Article
- Insect Transcription Factors: A Landscape of Their Structures and Biological Functions inInternational journal of molecular sciences · 2018Review
- Drosophila nucleostemin 3 is required to maintain larval neuroblast proliferation.Developmental biology · 2018Article
- EC-tagging allows cell type-specific RNA analysis.Nucleic acids research · 2017Article
- Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues.Development (Cambridge, England) · 2016Article
- Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting.Development (Cambridge, England) · 2016Article
- Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes.Genetics · 2016Article
- Aneuploidy causes premature differentiation of neural and intestinal stem cells.Nature communications · 2015Article
- Gut stem cells, a story of snails, flies and mice.The EMBO journal · 2015Article
- Dynamic regulation of mRNA decay during neural development.Neural development · 2015Article
- Getting Down to Specifics: Profiling Gene Expression and Protein-DNA Interactions in a Cell Type-Specific Manner.Advances in genetics · 2015Review
- Article
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4 authors.
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Abstract
Snail family transcription factors are best known for regulating epithelial-mesenchymal transition (EMT). The Drosophila Snail family member Worniu is specifically transcribed in neural progenitors (neuroblasts) throughout their lifespan, and worniu mutants show defects in neuroblast delamination (a form of EMT). However, the role of Worniu in neuroblasts beyond their formation is unknown. We performed RNA-seq on worniu mutant larval neuroblasts and observed reduced cell-cycle transcripts and increased neural differentiation transcripts. Consistent with these genomic data, worniu mutant neuroblasts showed a striking delay in prophase/metaphase transition by live imaging and increased levels of the conserved neuronal differentiation splicing factor Elav. Reducing Elav levels significantly suppressed the worniu mutant phenotype. We conclude that Worniu is continuously required in neuroblasts to maintain self-renewal by promoting cell-cycle progression and inhibiting premature differentiation.
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