ArticleDevelopmental cell2012
BMP signaling protects telencephalic fate by repressing eye identity and its Cxcr4-dependent morphogenesis.
Article in Developmental cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
- Holoprosencephaly and cyclopia inAnimal cells and systems · 2025Article
- Molecular analysis of RAX2-regulated retinal development using human retinal organoids at a single-cell resolution.Frontiers in cell and developmental biology · 2025Article
- Short-range Fgf signalling patterns hindbrain progenitors to induce the neurogenesis-to-oligodendrogenesis switch.Development (Cambridge, England) · 2024Article
- Cxcr4a regulates heart progenitor development and cardiac rhythm in zebrafish.Biochemistry and biophysics reports · 2024Article
- Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos.Development, growth & differentiation · 2024Article
- Progress in Stem Cells-Based Replacement Therapy for Retinal Pigment Epithelium: In Vitro Differentiation to In Vivo Delivery.Stem cells translational medicine · 2023Review
- Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction ofInternational journal of molecular sciences · 2023Article
- Overview of Head Muscles with Special Emphasis on Extraocular Muscle Development.Advances in anatomy, embryology, and cell biology · 2023Article
- Cell fate decisions, transcription factors and signaling during early retinal development.Progress in retinal and eye research · 2022Review
- Article
- Genome-enabled discovery of evolutionary divergence in brains and behavior.Scientific reports · 2021Article
- Looking to the future of zebrafish as a model to understand the genetic basis of eye disease.Human genetics · 2019Review
- Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye.PLoS genetics · 2018Article
- Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks.PLoS genetics · 2018Article
- The fly eye: Through the looking glass.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis.Frontiers in neuroscience · 2018Review
- Whole-Exome Sequencing of Congenital Glaucoma Patients Reveals Hypermorphic Variants in GPATCH3, a New Gene Involved in Ocular and Craniofacial Development.Scientific reports · 2017Article
- Coordinated Morphogenetic Mechanisms Shape the Vertebrate Eye.Frontiers in neuroscience · 2017Article
- Rx3 and Shh direct anisotropic growth and specification in the zebrafish tuberal/anterior hypothalamus.Development (Cambridge, England) · 2016Article
- Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish.Development (Cambridge, England) · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Depletion of Wnt signaling is a major requirement for the induction of the anterior prosencephalon. However, the molecular events driving the differential regionalization of this area into eye-field and telencephalon fates are still unknown. Here we show that the BMP pathway is active in the anterior neural ectoderm during late blastula to early gastrula stage in zebrafish. Bmp2b mutants and mosaic loss-of-function experiments reveal that BMP acts as a repressor of eye-field fate through inhibition of its key transcription factor Rx3, thereby protecting the future telencephalon from acquiring eye identity. This BMP-driven mechanism initiates the establishment of the telencephalon prior to the involvement of Wnt antagonists from the anterior neural border. Furthermore, we demonstrate that Rx3 and BMP are respectively required to maintain and restrict the chemokine receptor cxcr4a, which in turn contributes to the morphogenetic separation of eye-field and telencephalic cells during early neurulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.