ReviewJournal of the International AIDS Society2012
Challenges and opportunities for the implementation of virological testing in resource-limited settings.
Review in Journal of the International AIDS Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Pooled it
- Systematic review of the use of dried blood spots for monitoring HIV viral load and for early infant diagnosis.PloS one · 2014Pooled it
- Trial
- Trial
- Predictive factors of plasma HIV suppression during pregnancy: a prospective cohort study in Benin.PloS one · 2013Trial
- Changes in access to viral load testing, incidence rates of viral load suppression and rebound following the introduction of the 'universal test and treat' guidelines in Cameroon: A retrospective follow-up analysis.PLOS global public health · 2024Article
- The rollout of paediatric dolutegravir and virological outcomes among children living with HIV in Mozambique.Southern African journal of HIV medicine · 2024Article
- Article
- Measuring and explaining inequality of continuous care for people living with HIV receiving antiretroviral therapy in Kunming, China.PloS one · 2021Article
- Incidence and predictors of virological failure among adult HIV patients on first-line antiretroviral therapy in Amhara regional referral hospitals; Ethiopia: a retrospective follow-up study.BMC infectious diseases · 2020Article
- Infant HIV diagnosis and turn-around time for testing in Malawi, 2015.African journal of laboratory medicine · 2020Article
- An open-source molecular diagnostic platform approach for outbreak and epidemic preparedness.African journal of laboratory medicine · 2020Article
- Pooled testing: A tool to increase efficiency of infant HIV diagnosis and virological monitoring.African journal of laboratory medicine · 2020Review
- Challenges and barriers to HIV service uptake and delivery along the HIV care cascade in Cameroon.The Pan African medical journal · 2020Article
- Point-of-care viral load monitoring: outcomes from a decentralized HIV programme in Malawi.Journal of the International AIDS Society · 2019Article
- Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease.BMJ global health · 2019Article
- An updated roadmap for MERS-CoV research and product development: focus on diagnostics.BMJ global health · 2019Article
- A targeted approach for routine viral load monitoring in Malawian adults on antiretroviral therapy.Tropical medicine & international health : TM & IH · 2018Article
- Sensitive Fluorescent Sensor for Recognition of HIV-1 dsDNA by Using Glucose Oxidase and Triplex DNA.Journal of analytical methods in chemistry · 2018Article
- Multidisease testing for HIV and TB using the GeneXpert platform: A feasibility study in rural Zimbabwe.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though the advantages of routine virological monitoring for patients on anti-retroviral therapy have been established, cost and complexity limit its full implementation. Monitoring is important for diagnosing virological failure early on, before the development of drug resistance mutations, and to trigger early adherence interventions. Simple and cost-effective viral load tests that facilitate simplification and decentralization of testing and strategies, such as the use of dried blood spots and pooled sample testing, which further aid simplification, are becoming available. In addition, replacing immunological monitoring with virological monitoring in non-viremic patients in a phased manner will reduce the costs associated with dual immuno-virological monitoring. Going forward, the simplification of testing paired with price reducing strategies that will allow for healthy competition between multiple manufacturers will enable the implementation of viral load testing in resource-poor settings. It is important that future HIV and AIDS treatment guidelines provide clear recommendations for routine virological monitoring and that governments and donors fund the implementation of accurate and operationally proven testing platforms in a comprehensive manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.