ArticleCritical care (London, England)2012
Protective effects of aerobic exercise on acute lung injury induced by LPS in mice.
Article in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 82 citations in OpenAlex.
- The effect of aerobic exercise on immune biomarkers and symptoms severity and progression in patients with COVID-19: A randomized control trial.Journal of bodywork and movement therapies · 2021Trial
- Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.Science translational medicine · 2015Trial
- Organ-specific modulation of antioxidant functions by combined voluntary exercise and radon inhalation in mice.Journal of clinical biochemistry and nutrition · 2026Article
- Regular aerobic exercise ameliorates radiation-induced pulmonary fibrosis: An animal study.Clinical and translational radiation oncology · 2025Article
- Effect of exercise on postoperative recovery of patients with non-small cell lung cancer: a systematic review and meta-analysis.Discover oncology · 2024Article
- Aerobic physical training reduces severe asthma phenotype involving kinins pathway.Molecular biology reports · 2024Article
- High-intensity intermittent training ameliorates methotrexate-induced acute lung injury.BMC pulmonary medicine · 2024Article
- Lung molecular and histological changes in type 2 diabetic rats and its improvement by high-intensity interval training.BMC pulmonary medicine · 2024Article
- Exercise preconditioning and resveratrol reduce the susceptibility of rats with obstructive jaundice to endotoxin and alleviate lung injury.Frontiers in immunology · 2024Article
- Role of Enhancing Aerobic Capacity in Countering COVID-19-induced Liver Injury in Elderlies.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise.Molecular and cellular biochemistry · 2023Review
- Aerobic exercise alleviates ventilator-induced lung injury by inhibiting NLRP3 inflammasome activation.BMC anesthesiology · 2022Article
- Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury.Journal of ethnopharmacology · 2022Article
- Exercise duration modulates upper and lower respiratory fluid cellularity, antiviral activity, and lung gene expression.Physiological reports · 2021Article
- Aerobic exercise improves LPS-induced sepsis via regulating the Warburg effect in mice.Scientific reports · 2021Article
- Potential Physiological and Cellular Mechanisms of Exercise That Decrease the Risk of Severe Complications and Mortality Following SARS-CoV-2 Infection.Sports (Basel, Switzerland) · 2021Review
- Enhancing oxygenation of patients with coronavirus disease 2019: Effects on immunity and other health-related conditions.World journal of clinical cases · 2021Review
- Effect of Aerobic Exercise on Oxidative Stress and Inflammatory Response During Particulate Matter Exposure in Mouse Lungs.Frontiers in physiology · 2021Article
- Impacts of exercise interventions on different diseases and organ functions in mice.Journal of sport and health science · 2020Review
- Exercise Improves Lung Inflammation, but Not Lung Remodeling and Mechanics in a Model of Bleomycin-Induced Lung Fibrosis.Oxidative medicine and cellular longevity · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe regular practice of physical exercise has been associated with beneficial effects on various pulmonary conditions. We investigated the mechanisms involved in the protective effect of exercise in a model of lipopolysaccharide (LPS)-induced acute lung injury (ALI).
methodsMice were divided into four groups: Control (CTR), Exercise (Exe), LPS, and Exercise + LPS (Exe + LPS). Exercised mice were trained using low intensity daily exercise for five weeks. LPS and Exe + LPS mice received 200 µg of LPS intratracheally 48 hours after the last physical test. We measured exhaled nitric oxide (eNO); respiratory mechanics; neutrophil density in lung tissue; protein leakage; bronchoalveolar lavage fluid (BALF) cell counts; cytokine levels in BALF, plasma and lung tissue; antioxidant activity in lung tissue; and tissue expression of glucocorticoid receptors (Gre).
resultsLPS instillation resulted in increased eNO, neutrophils in BALF and tissue, pulmonary resistance and elastance, protein leakage, TNF-alpha in lung tissue, plasma levels of IL-6 and IL-10, and IL-1beta, IL-6 and KC levels in BALF compared to CTR (P ≤0.02). Aerobic exercise resulted in decreases in eNO levels, neutrophil density and TNF-alpha expression in lung tissue, pulmonary resistance and elastance, and increased the levels of IL-6, IL-10, superoxide dismutase (SOD-2) and Gre in lung tissue and IL-1beta in BALF compared to the LPS group (P ≤0.04).
conclusionsAerobic exercise plays important roles in protecting the lungs from the inflammatory effects of LPS-induced ALI. The effects of exercise are mainly mediated by the expression of anti-inflammatory cytokines and antioxidants, suggesting that exercise can modulate the inflammatory-anti-inflammatory and the oxidative-antioxidative balance in the early phase of ALI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.