Evidence map›Paper›PMID 23078595›Full record

ArticleJournal of medical primatology2012

Enhancing genotyping of MAOA-LPR and 5-HTT-LPR in rhesus macaques (Macaca mulatta).

Genesio M Karere, Erin Sullivan, Erin L Kinnally, John P Capitanio, Leslie A Lyons

Abstract read
In one paragraph

Article in Journal of medical primatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Genesio M KarereDepartment of Population Health and Reproduction, University of California-Davis, Davis, CA, USA. gmkarere@txbiomedgenetics.org
Erin Sullivan
Erin L Kinnally
John P Capitanio
Leslie A Lyons

Funding

ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI HYDE, DALLAS MELVIN · 1985 to 2011
$126.2M
Biobehavioral characterization of infant rhesus monkeysR24OD010962 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CAPITANIO, JOHN P · 2012 to 2018
$2.5M
Biobehavioral Characterization of Infant Rhesus MonkeysR24RR019970 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI CAPITANIO, JOHN P · 2004 to 2011
$2.5M
GENETIC RESOURCES FOR NON-HUMAN PRIMATESR24RR017584 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI LYONS, LESLIE A · 2003 to 2007
$1.3M
NCRR NIH HHS P51 RR000169NCRR NIH HHS R24 RR017584NCRR NIH HHS R24 RR019970NCRR NIH HHS RR000169NCRR NIH HHS RR017584NCRR NIH HHS RR019970NIH HHS R24 OD010962
6 · The paper itself

Abstract

backgroundGenetic variation in monoamine oxidase A (MAOA) and serotonin transporter (5-HTT)-linked polymorphic regions (LPR) is associated with neuropsychiatric behavior.

methodsWe genotyped 37 macaques using conventional PCR product gel fractionation and by capillary electrophoresis of multiplexed amplicons and compared the data.

resultsGenotype concordance was 97% and 95% for MAOA-LPR and 5-HTT-LPR, respectively. Capillary electrophoresis was more sensitive and cost-effective.

conclusionsMultiplexing MAOA-LPR and 5-HTT-LPR will enhance the genotyping of large sample sets.

Indexed as

Behavior, AnimalAnimalsDNAElectrophoresis, CapillaryFemaleGenotyping TechniquesMacaca mulattaMaleMonoamine OxidasePolymerase Chain ReactionPolymorphism, GeneticSerotonin Plasma Membrane Transport ProteinsDNAMonoamine OxidaseSerotonin Plasma Membrane Transport Proteins

Identifiers

PMID23078595
PMCPMC3492537

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.