ArticleBMC neuroscience2012
High throughput analysis reveals dissociable gene expression profiles in two independent neural systems involved in the regulation of social behavior.
Article in BMC neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 28 citations in OpenAlex.
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- Unraveling the Role of Thyroid Hormones in Seasonal Neuroplasticity in European Starlings (Frontiers in molecular neuroscience · 2022Article
- Sex differences and similarities in the neural circuit regulating song and other reproductive behaviors in songbirds.Neuroscience and biobehavioral reviews · 2020Review
- ZEBrA: Zebra finch Expression Brain Atlas-A resource for comparative molecular neuroanatomy and brain evolution studies.The Journal of comparative neurology · 2020Article
- Co-localization of mu-opioid and dopamine D1 receptors in the medial preoptic area and bed nucleus of the stria terminalis across seasonal states in male European starlings.Hormones and behavior · 2019Article
- Curation of microarray oligonucleotides and corresponding ESTs/cDNAs used for gene expression analysis in zebra finches.BMC research notes · 2018Article
- The constitutive differential transcriptome of a brain circuit for vocal learning.BMC genomics · 2018Article
- The Value of Comparative Animal Research: Krogh's Principle Facilitates Scientific Discoveries.Policy insights from the behavioral and brain sciences · 2018Article
- The opportunities and challenges of large-scale molecular approaches to songbird neurobiology.Neuroscience and biobehavioral reviews · 2015Review
- Using the canary genome to decipher the evolution of hormone-sensitive gene regulation in seasonal singing birds.Genome biology · 2015Article
- Photoperiod-dependent regulation of gonadotropin-releasing hormone 1 messenger ribonucleic acid levels in the songbird brain.General and comparative endocrinology · 2013Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundProduction of contextually appropriate social behaviors involves integrated activity across many brain regions. Many songbird species produce complex vocalizations called 'songs' that serve to attract potential mates, defend territories, and/or maintain flock cohesion. There are a series of discrete interconnect brain regions that are essential for the successful production of song. The probability and intensity of singing behavior is influenced by the reproductive state. The objectives of this study were to examine the broad changes in gene expression in brain regions that control song production with a brain region that governs the reproductive state.
resultsWe show using microarray cDNA analysis that two discrete brain systems that are both involved in governing singing behavior show markedly different gene expression profiles. We found that cortical and basal ganglia-like brain regions that control the socio-motor production of song in birds exhibit a categorical switch in gene expression that was dependent on their reproductive state. This pattern is in stark contrast to the pattern of expression observed in a hypothalamic brain region that governs the neuroendocrine control of reproduction. Subsequent gene ontology analysis revealed marked variation in the functional categories of active genes dependent on reproductive state and anatomical localization. HVC, one cortical-like structure, displayed significant gene expression changes associated with microtubule and neurofilament cytoskeleton organization, MAP kinase activity, and steroid hormone receptor complex activity. The transitions observed in the preoptic area, a nucleus that governs the motivation to engage in singing, exhibited variation in functional categories that included thyroid hormone receptor activity, epigenetic and angiogenetic processes.
conclusionsThese findings highlight the importance of considering the temporal patterns of gene expression across several brain regions when engaging in social behaviors.
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