Trial reportJournal of human nutrition and dietetics : the official journal of the British Dietetic Association2013
A reduced-energy intake, well-balanced diet improves weight control in children with Prader-Willi syndrome.
Trial report in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Methods of Determining Energy Expenditure in Individuals with Prader-Willi Syndrome: A Systematic Literature Review.Nutrients · 2024Pooled it
- Energy Metabolism Profile in Individuals with Prader-Willi Syndrome and Implications for Clinical Management: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- Dietary Modulation of Gut Microbiota Contributes to Alleviation of Both Genetic and Simple Obesity in Children.EBioMedicine · 2015Trial
- A scoping review of dietary interventions to treat obesity among Prader-Willi syndrome individuals.Intractable & rare diseases research · 2025Review
- Effect of Dietary Fiber Intake on Chronic Low-Grade Inflammation in Children and Adolescents: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Current developments in nutrition · 2025Review
- Measured Resting Energy Expenditure by Indirect Calorimetry and Energy Intake in Long-Term Growth Hormone-Treated Children with PWS.Hormone research in paediatrics · 2025Article
- Clarifying main nutritional aspects and resting energy expenditure in children with Smith-Magenis syndrome.European journal of pediatrics · 2024Article
- Household food security, child dietary diversity and coping strategies among rural households. The case of Kole District in northern Uganda.Dialogues in health · 2023Article
- Management of Hyperphagia and Obesity in Prader-Willi Syndrome.Ewha medical journal · 2023Review
- Article
- Hyperinsulinemia is a probable trigger for weight gain and hyperphagia in individuals with Prader-Willi syndrome.Obesity science & practice · 2023Article
- A Personalized Approach to Determining the Caloric Needs of Children with Prader-Willi Syndrome Treated with Growth Hormone.Journal of clinical medicine · 2023Article
- Prader-Willi Syndrome and Weight Gain Control: From Prevention to Surgery-A Narrative Review.Children (Basel, Switzerland) · 2023Review
- Prader-Willi Syndrome in Adults: An Update On Nutritional Treatment and Pharmacological Approach.Current obesity reports · 2022Review
- Article
- Review
- The Hyperphagia Questionnaire: Insights From a Multicentric Validation Study in Individuals With Prader Willi Syndrome.Frontiers in pediatrics · 2022Article
- Obesity in Prader-Willi syndrome: physiopathological mechanisms, nutritional and pharmacological approaches.Journal of endocrinological investigation · 2021Review
- Changes of Body Weight and Body Composition in Obese Patients with Prader-Willi Syndrome at 3 and 6 Years of Follow-Up: A Retrospective Cohort Study.Journal of clinical medicine · 2020Article
- Prader-Willi syndrome: reflections on seminal studies and future therapies.Open biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChildren with Prader-Willi syndrome (PWS) have a predictable pattern of weight gain, with obesity beginning in early childhood and worsening as they get older and hyperphagia increases. Data on the most effective dietary modifications are scant and primarily anecdotal. As part of a longitudinal study investigating the natural history of PWS, we evaluated the effect of a well-balanced, energy-restricted diet on body composition and weight in young children with PWS.
methodsSixty-three children, aged 2-10 years, with genetically proven PWS participated in the present study. These children had measurements of body composition by dual-energy X-ray absorptiometry and resting energy expenditure (REE), as well as a 3-day diet history analysis both before and after intervention. Energy calculations were based on the individual's REE, with the recommendation that the macronutrients of the diet consist of 30% fat, 45% carbohydrates and 25% protein, with at least 20 g of fibre per day.
resultsThirty-three families adhered to our dietary recommendations for both energy intake and macronutrient distribution. Those 33 children had lower body fat (19.8% versus 41.9%; P < 0.001) and weight management (body mass index SD score 0.3 versus 2.23; P < 0.001) than those whose parents followed the energy intake recommendations but did not alter the macronutrient composition of the diet. Those who followed our recommendations also had a lower respiratory quotient (0.84 versus 0.95; P = 0.002).
conclusionsOur recommendation for an energy-restricted diet with a well-balanced macronutrient composition and fibre intake improves both weight and body composition in children with PWS compared to a simple energy-restricted diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.