ReviewDrug safety2012
Balancing the risks and benefits of the use of over-the-counter pain medications in children.
Review in Drug safety, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Antipyretic effect of oral dipyrone (Metamizole) compared to oral ibuprofen in febrile children: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Alternating Acetaminophen and Ibuprofen versus Monotherapies in Improvements of Distress and Reducing Refractory Fever in Febrile Children: A Randomized Controlled Trial.Paediatric drugs · 2017Trial
- Self-medication with NSAIDs and purchase of branded and over-the-counter medicines: Analysis of a national survey in Peru.Journal of public health research · 2025Article
- The impact of using pictorial aids in caregivers' understanding of patient information leaflets of pediatric pain medications: A quasi-experimental study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies.Journal of asthma and allergy · 2022Review
- Long-term exposure of marine mussels to paracetamol: is time a healer or a killer?Environmental science and pollution research international · 2021Article
- Management of acute fever in children: Consensus recommendations for community and primary healthcare providers in sub-Saharan Africa.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2021Review
- Frequency and Nature of Adverse Drug Reactions Due to Non-Prescription Drugs in Children: A Retrospective Analysis from the French Pharmacovigilance Database.Paediatric drugs · 2018Article
- Over-the-Counter Drugs and Complementary Medications Use among Children in Southern Italy.BioMed research international · 2015Article
- In reply.Deutsches Arzteblatt international · 2014Article
- Tonsillitis and sore throat in children.GMS current topics in otorhinolaryngology, head and neck surgery · 2014Review
- Application of physiologically based pharmacokinetic modeling to predict acetaminophen metabolism and pharmacokinetics in children.CPT: pharmacometrics & systems pharmacology · 2013Article
- [Pediatric postoperative quality analysis : Pain and postoperative nausea and vomiting].Der Anaesthesist · 2013Article
- Pharmacological treatment of acute migraine in adolescents and children.Paediatric drugs · 2013Review
- USE OF DRUGS IN CHILDREN AGED ZERO TO FIVE YEARS OLD IN TUBARÃO, SANTA CATARINA, BRAZIL.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paracetamol (acetaminophen) and ibuprofen are the most frequently purchased over-the-counter (OTC) medicines for children. Parents purchase these medicines for the treatment of fever and pain. In some countries other NSAIDs such as aspirin (acetylsalicylic acid) and dipyrone are available. We aimed to perform a narrative review of the efficacy and toxicity of OTC analgesic medicines for children in order to give guidance to health professionals and parents regarding the treatment of pain in a child. Neither aspirin nor dipyrone are recommended for OTC use because of the association with Reye's syndrome for the former and the risk of agranulocytosis for the latter. Both paracetamol and ibuprofen are effective for the treatment of mild pain in children. Adverse effects with both medicines are infrequent. Ibuprofen is an NSAID and therefore there is a greater risk of gastrointestinal adverse effects and hypersensitivity. Aspirin and dipyrone should be avoided. Paracetamol is the drug of first choice for mild pain in children because of its favourable safety profile. For the treatment of significant musculoskeletal pain, ibuprofen is the drug of first choice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.