Trial reportPloS one2012
Sensitive troponins--which suits better for hemodialysis patients? Associated factors and prediction of mortality.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Dry weight assessment by combined ultrasound and bioimpedance monitoring in low cardiovascular risk hemodialysis patients: a randomized controlled trial.International urology and nephrology · 2017Trial
- Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.PloS one · 2014Trial
- Novel Biomarkers and Their Role in the Diagnosis and Prognosis of Acute Coronary Syndrome.Life (Basel, Switzerland) · 2023Review
- Benefits of Preserving Residual Urine Output in Patients Undergoing Maintenance Haemodialysis.International journal of nephrology and renovascular disease · 2023Article
- Prognostic values of high sensitivity cardiac troponin T and I for long-term mortality in hemodialysis patients.Scientific reports · 2022Article
- Elevation of Highly Sensitive Cardiac Troponin T Among End-Stage Renal Disease Patients Without Acute Coronary Syndrome.The Malaysian journal of medical sciences : MJMS · 2021Article
- Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- Variability of high-sensitivity cardiac troponin T and I in asymptomatic patients receiving hemodialysis.Scientific reports · 2021Article
- High-sensitivity troponins in dialysis patients: variation and prognostic value.Clinical kidney journal · 2021Article
- Discordance of High-Sensitivity Troponin Assays in Patients With Suspected Acute Coronary Syndromes.Journal of the American College of Cardiology · 2021Article
- Prognostic value of high-sensitive cardiac troponin I in asymptomatic chronic hemodialysis patients.Journal of nephrology · 2020Article
- High sensitivity Troponin-I levels in asymptomatic hemodialysis patients.Renal failure · 2019Article
- Associations of sensitive cardiac troponin-I with left ventricular morphology, function and prognosis in end-stage renal disease patients with preserved ejection fraction.Heart and vessels · 2018Article
- Systemic haemodynamics in haemodialysis: intradialytic changes and prognostic significance.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- High-Sensitivity Troponin T and C-Reactive Protein Have Different Prognostic Values in Hemo- and Peritoneal Dialysis Populations: A Cohort Study.Journal of the American Heart Association · 2018Observational
- Remote ischemic preconditioning in myocardial protection in hemodialysis patients.International journal of general medicine · 2018Article
- Serum cardiac troponin T and effective blood flow in stable extracorporeal dialysis patients.International urology and nephrology · 2016Article
- Optimal Cutoff Levels of More Sensitive Cardiac Troponin Assays for the Early Diagnosis of Myocardial Infarction in Patients With Renal Dysfunction.Circulation · 2015Article
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Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn hemodialysis patients, elevated plasma troponin concentrations are a common finding that has even increased with the advent of newly developed sensitive assays. However, the interpretation and relevance of this is still under debate.
methodsIn this cross-sectional study, we analyzed plasma concentrations of sensitive troponin I (TnI) and troponin T (TnT) in stable ambulatory hemodialysis patients (n = 239) and investigated their associations with clinical factors and mortality.
resultsIn all of the enrolled patients, plasma TnI or TnT was detectable at a median concentration of 14 pg/ml (interquartile range: 7-29) using the Siemens TnI ultra assay and 49 pg/ml (31-74) using the Roche Elecsys high sensitive TnT assay. Markedly more patients exceeded the 99th percentile for TnT than for TnI (95% vs. 14%, p<0.0001). In a multivariate linear regression model, TnT was independently associated with age, gender, systolic dysfunction, time on dialysis, residual diuresis and systolic blood pressure, whereas TnI was independently associated with age, systolic dysfunction, pulse pressure, time on dialysis and duration of a HD session. During a follow-up period of nearly two years, TnT concentration above 38 pg/mL was associated with a 5-fold risk of death, whereas elevation of TnI had a gradual association to mortality.
conclusionIn hemodialysis patients, elevations of plasma troponin concentrations are explained by cardiac function and dialysis-related parameters, which contribute to cardiac strain. Both are highly predictive of increased risk of death.
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