Evidence map›Paper›PMID 23077622›Full record

ArticlePloS one2012

Transcranial red and near infrared light transmission in a cadaveric model.

Jared R Jagdeo, Lauren E Adams, Neil I Brody, Daniel M Siegel

3 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 91 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 6 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02630303 phase1completednot on this mapstarted 2016, after this paper: background citation

Phase I Study of High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin

TypeinterventionalSponsorJared Jagdeo, MD, MSRan2016 to 2017Enrolled60ConditionsFibrosis, Scarring, Scar, WoundsArmsLED-RL Phototherapy, Mock Therapy
NCT03433222 phase1unknown statusnot on this mapstarted 2018, after this paper: background citation

EBIRE: Phase 1 Study of High Fluence LED-Red Light in Fitzpatrick Skin Types I to III

TypeinterventionalSponsorVA Northern California Health Care SystemRan2018 to 2019Enrolled60ConditionsSkin Diseases, Keloid, Scar, FibrosisArmsHF-LED-RL Phototherapy, Mock Therapy
NCT03461731 nacompletednot on this mapstarted 2017, after this paper: background citation

Investigation of the Role of 905-nm Laser Light in the Delay of Muscle Fatigue

TypeinterventionalSponsorCollege of CharlestonRan2017 to 2017Enrolled29ConditionsMuscle FatigueArmsControl, 800 nm laser, combination laser, 905 nm laser
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 6 syntheses or guidelines pooled it, 195 citations in OpenAlex.

  1. Pooled it
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  3. Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis.Photobiomodulation, photomedicine, and laser surgery · 2023
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  13. [A simulation study of photothermal effects in transcranial photobiomodulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jared R JagdeoDepartment of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York, United States of America. jrjagdeo@gmail.com
Lauren E Adams
Neil I Brody
Daniel M Siegel
State University of New York · USSUNY Downstate Health Sciences University · USVeterans Health Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveLow level light therapy has garnered significant interest within the past decade. The exact molecular mechanisms of how red and near infrared light result in physiologic modulation are not fully understood. Heme moieties and copper within cells are red and near infrared light photoreceptors that induce the mitochondrial respiratory chain component cytochrome C oxidase, resulting in a cascade linked to cytoprotection and cellular metabolism. The copper centers in cytochrome C oxidase have a broad absorption range that peaks around 830 nm. Several in vitro and in vivo animal and human models exist that have demonstrated the benefits of red light and near infrared light for various conditions. Clinical applications for low level light therapy are varied. One study in particular demonstrated improved durable functional outcomes status post-stroke in patients treated with near infrared low level light therapy compared to sham treatment [1]. Despite previous data suggesting the beneficial effect in treating multiple conditions, including stroke, with low level light therapy, limited data exists that measures transmission in a human model. STUDY DESIGN/MATERIALS AND

methodsTo investigate this idea, we measured the transmission of near infrared light energy, using red light for purposes of comparison, through intact cadaver soft tissue, skull bones, and brain using a commercially available LED device at 830 nm and 633 nm.

resultsOur results demonstrate that near infrared measurably penetrates soft tissue, bone and brain parenchyma in the formalin preserved cadaveric model, in comparison to negligible red light transmission in the same conditions.

conclusionThese findings indicate that near infrared light can penetrate formalin fixed soft tissue, bone and brain and implicate that benefits observed in clinical studies are potentially related to direct action of near infrared light on neural tissue.

Indexed as

Infrared RaysPhototherapyBrainCadaverCopperElectron Transport Complex IVHemeHumansMaleSkullCopperElectron Transport Complex IVHeme

Identifiers

PMID23077622
PMCPMC3471828
OpenAlexW2092584918

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.