ArticlePloS one2012
Novel inhibitors of Staphylococcus aureus virulence gene expression and biofilm formation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Stage V sporulation protein G as a global regulator of biofilm formation and virulence in Staphylococcus species: molecular mechanisms and therapeutic potential.World journal of microbiology & biotechnology · 2026Review
- Virulence Profiling of Multidrug-Resistant ClinicalMicrobial drug resistance (Larchmont, N.Y.) · 2026Article
- Analysis of the virulence potential, ability to form biofilms and susceptibility to bacteriocins ofJournal of veterinary research · 2026Article
- Attenuation ofAntibiotics (Basel, Switzerland) · 2025Article
- The mechanisms of antibiotic resistance and drug resistance transmission of Klebsiella pneumoniae.The Journal of antibiotics · 2025Review
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- Antibacterial and Anti-Biofilm Activity of Pyrones from aAntibiotics (Basel, Switzerland) · 2022Article
- Bioactive Efficacy of Novel Carboxylic Acid from HalophilicMetabolites · 2022Article
- Phenotypic and Genotypic Detection of Biofilm-FormingBiology · 2022Article
- Colonization and Infection of Indwelling Medical Devices byInternational journal of molecular sciences · 2022Review
- Clearance of mixed biofilms of Streptococcus pneumoniae and methicillin-susceptible/resistant Staphylococcus aureus by antioxidants N-acetyl-L-cysteine and cysteamine.Scientific reports · 2022Article
- Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Review
- Inhibition of Biofilm Formation of FoodborneFoods (Basel, Switzerland) · 2021Article
- Article
- Preparation and Pharmacokinetic Characterization of an Anti-Virulence Compound Nanosuspensions.Pharmaceutics · 2021Article
- Citral modulates virulence factors in methicillin-resistant Staphylococcus aureus.Scientific reports · 2021Article
- Staphylococcal Biofilms: Challenges and Novel Therapeutic Perspectives.Antibiotics (Basel, Switzerland) · 2021Review
- Physicochemical properties and formulation development of a novel compound inhibiting Staphylococcus aureus biofilm formation.PloS one · 2021Article
- A Substituted Diphenyl Amide Based Novel Scaffold InhibitsFrontiers in microbiology · 2021Article
- Characterization of biofilm formation and virulence factors ofIranian journal of basic medical sciences · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Staphylococcus aureus is a major human pathogen and one of the more prominent pathogens causing biofilm related infections in clinic. Antibiotic resistance in S. aureus such as methicillin resistance is approaching an epidemic level. Antibiotic resistance is widespread among major human pathogens and poses a serious problem for public health. Conventional antibiotics are either bacteriostatic or bacteriocidal, leading to strong selection for antibiotic resistant pathogens. An alternative approach of inhibiting pathogen virulence without inhibiting bacterial growth may minimize the selection pressure for resistance. In previous studies, we identified a chemical series of low molecular weight compounds capable of inhibiting group A streptococcus virulence following this alternative anti-microbial approach. In the current study, we demonstrated that two analogs of this class of novel anti-virulence compounds also inhibited virulence gene expression of S. aureus and exhibited an inhibitory effect on S. aureus biofilm formation. This class of anti-virulence compounds could be a starting point for development of novel anti-microbial agents against S. aureus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.