ArticlePloS one2012
White blood cell count and the risk for coronary artery disease in young adults.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 74 citations in OpenAlex.
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- The effect of nitrates in patients with coronary artery disease across different left ventricular ejection fractions.Frontiers in cardiovascular medicine · 2026Article
- Racial differences in hematologic profiles among men with erectile dysfunction: a cross-sectional analysis of NHANES 2001-2004.Translational andrology and urology · 2025Article
- Review
- Exploring the Link between Inflammatory Biomarkers and Adipometrics in Healthy Young Adults Aged 20-35 Years.Nutrients · 2024Article
- Association of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio and Coronary Artery Disease Among the Physicians.Journal of inflammation research · 2024Article
- The levels of systemic inflammatory markers exhibit a positive correlation with the occurrence of heart failure: a cross-sectional study from NHANES.Frontiers in cardiovascular medicine · 2024Article
- Article
- Distinct WBC Trajectories are Associated with the Risks of Incident CVD and All-Cause Mortality.Journal of atherosclerosis and thrombosis · 2023Article
- Associations of Baseline and Changes in Leukocyte Counts with Incident Cardiovascular Events: The Dongfeng-Tongji Cohort Study.Journal of atherosclerosis and thrombosis · 2022Article
- The Relationship Between Hematologic Parameters and Erectile Dysfunction.Sexual medicine · 2021Article
- Consistency where it counts: Sleep regularity is associated with circulating white blood cell count in young adults.Brain, behavior, & immunity - health · 2021Article
- Association between White Blood Cells Count and Diabetes Mellitus in Tabari Cohort Study: A Case-Control Study.International journal of preventive medicine · 2021Article
- Baseline white blood cell count-to-apolipoprotein A1 ratio as a novel predictor of long-term adverse outcomes in patients who underwent percutaneous coronary intervention: a retrospective cohort study.Lipids in health and disease · 2020Article
- Inflammatory Markers and Plasma Fatty Acids in Predicting WBC Level Alterations in Association With Glucose-Related Markers: A Cross-Sectional Study.Frontiers in immunology · 2020Article
- Association between lifestyle and hematological parameters: A study of Chinese male steelworkers.Journal of clinical laboratory analysis · 2019Article
- Six-year follow-up study on the association between white blood cell count and fasting blood glucose level in Chinese adults: A community-based health examination survey.Diabetes/metabolism research and reviews · 2019Article
- Gender Dictates the Relationship between Serum Lipids and Leukocyte Counts in the National Health and Nutrition Examination Survey 1999⁻2004.Journal of clinical medicine · 2019Article
- Lipoprotein Lipase Deficiency Impairs Bone Marrow Myelopoiesis and Reduces Circulating Monocyte Levels.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Fruit vinegars attenuate cardiac injury via anti-inflammatory and anti-adiposity actions in high-fat diet-induced obese rats.Pharmaceutical biology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe association between white blood cell (WBC) count and coronary artery disease (CAD) is unknown in young adults. Our objective was to assess the association between WBC count and its changes over time with CAD incidence in the Metabolic, Life-style and Nutrition Assessment in Young adults (MELANY) study, a cohort of Israeli army personnel. METHODS AND
findings29,120 apparently healthy young men (mean age; 31.2±5.5 years) with a normal baseline WBC count (3,000-12,000 cells/mm(3)) were followed during a mean follow up of 7.5±3.8 years for incidence of CAD. Participants were screened every 3-5 years using a stress test, and CAD was confirmed by coronary angiography. In a multivariate model adjusted for age, body mass index (BMI), LDL- and HDL-cholesterol, blood pressure, family history of CAD, physical activity, diabetes, triglycerides and smoking status, WBC levels (divided to quintiles) above 6,900 cells/mm(3) (quintile 4) were associated with a 2.17-fold increase (95%CI = 1.18-3.97) in the risk for CAD as compared with men in quintile 1 (WBC≤5,400 cells/mm(3)). When modeled as a continuous variable, a WBC increment of 1000 cells/mm(3) was associated with a 17.4% increase in CAD risk (HR 1.174; 95%CI = 1.067-1.290, p = 0.001). A decrease in the WBC level (within the normal range) during the follow-up period was associated with increased physical activity and decreased triglyceride levels as well as with reduced incidence of CAD.
conclusionsWBC count is an independent risk factor for CAD in young adults at values well within the normal range. WBC count may assist in detecting subgroups of young men at either low or high risk for progression to CAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.