ArticlePloS one2012
Protein tyrosine phosphatase-induced hyperactivity is a conserved strategy of a subset of baculoviruses to manipulate lepidopteran host behavior.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 88 citations in OpenAlex.
- Baculoviruses hijack host midgut-derived tachykinin to regulate phototactic climbing behavior and promote viral transmission.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Chemosensory protein 3 is a brain host factor for the induction of enhanced-locomotory activity in the BmNPV-silkworm infection model.PLoS pathogens · 2025Article
- Structure of AcMNPV nucleocapsid reveals DNA portal organization and packaging apparatus of circular dsDNA baculovirus.Nature communications · 2025Article
- Insect circadian plasticity as a proposed target for the expression of parasite extended phenotypes.Npj biological timing and sleep · 2025Review
- Baculovirus entry into the central nervous system ofOpen biology · 2024Article
- Article
- Small Talk: On the Possible Role of Trans-Kingdom Small RNAs during Plant-Virus-Vector Tritrophic Communication.Plants (Basel, Switzerland) · 2023Review
- Hijacking time: How Ophiocordyceps fungi could be using ant host clocks to manipulate behavior.Parasite immunology · 2022Review
- The PI3K/AKT Pathway andGenes · 2022Article
- The genus Entomophthora: bringing the insect destroyers into the twenty-first century.IMA fungus · 2021Review
- Article
- High-resolution analysis of baculovirus-induced host manipulation in the domestic silkworm,Parasitology · 2021Article
- Intraguild predation decreases predator fitness with potentially varying effects on pathogen transmission in a herbivore host.Oecologia · 2020Article
- Genetic Underpinnings of Host Manipulation byG3 (Bethesda, Md.) · 2020Article
- Entomopathogenic Viruses in the Neotropics: Current Status and Recently Discovered Species.Neotropical entomology · 2020Review
- Cross-talking between baculoviruses and host insects towards a successful infection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Phototransduction and circadian entrainment are the key pathways in the signaling mechanism for the baculovirus induced tree-top disease in the lepidopteran larvae.Scientific reports · 2018Article
- Insights into the Temporal Gene Expression Pattern in Lymantria dispar Larvae During the Baculovirus Induced Hyperactive Stage.Virologica Sinica · 2018Article
- Baculovirus PTP2 Functions as a Pro-Apoptotic Protein.Viruses · 2018Article
- Review
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many parasites manipulate host behavior to increase the probability of transmission. To date, direct evidence for parasitic genes underlying such behavioral manipulations is scarce. Here we show that the baculovirus Autographa californica nuclear polyhedrovirus (AcMNPV) induces hyperactive behavior in Spodoptera exigua larvae at three days after infection. Furthermore, we identify the viral protein tyrosine phosphatase (ptp) gene as a key player in the induction of hyperactivity in larvae, and show that mutating the catalytic site of the encoded phosphatase enzyme prevents this induced behavior. Phylogenetic inference points at a lepidopteran origin of the ptp gene and shows that this gene is well-conserved in a group of related baculoviruses. Our study suggests that ptp-induced behavioral manipulation is an evolutionarily conserved strategy of this group of baculoviruses to enhance virus transmission, and represents an example of the extended phenotype concept. Overall, these data provide a firm base for a deeper understanding of the mechanisms behind baculovirus-induced insect behavior.
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