ArticlePloS one2012
Reproducibility and respiratory function correlates of exhaled breath fingerprint in chronic obstructive pulmonary disease.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exhaled breath volatile organic compounds (VOCs) detection methods: GC-MS versus eNose in COPD diagnosis-a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- The Evolving Landscape of COPD Typization.Medicina (Kaunas, Lithuania) · 2026Review
- The exhaled breath pattern as a potential method for biometrics identification.Scientific reports · 2025Article
- A noninvasive strategy for multi-disease diagnosis via multi-sensor platform: integrative analysis of five years of exhaled breath-based diagnostics for seven diseases.Frontiers in bioengineering and biotechnology · 2025Article
- Three-Month Variability of Commonly Evaluated Biomarkers in Clinically Stable COPD.International journal of chronic obstructive pulmonary disease · 2023Observational
- [Lung function test in advanced age].Zeitschrift fur Gerontologie und Geriatrie · 2022Article
- Breath Analysis: A Promising Tool for Disease Diagnosis-The Role of Sensors.Sensors (Basel, Switzerland) · 2022Review
- A systematic review of the diagnostic accuracy of volatile organic compounds in airway diseases and their relation to markers of type-2 inflammation.ERJ open research · 2021Article
- The Role of Electronic Noses in Phenotyping Patients with Chronic Obstructive Pulmonary Disease.Biosensors · 2020Review
- A Low-Cost Breath Analyzer Module in Domiciliary Non-Invasive Mechanical Ventilation for Remote COPD Patient Monitoring.Sensors (Basel, Switzerland) · 2020Article
- A Sensor for Spirometric Feedback in Ventilation Maneuvers during Cardiopulmonary Resuscitation Training.Sensors (Basel, Switzerland) · 2019Article
- Screening of Obstructive Sleep Apnea Syndrome by Electronic-Nose Analysis of Volatile Organic Compounds.Scientific reports · 2017Article
- Aging Airways: between Normal and Disease. A Multidimensional Diagnostic Approach by Combining Clinical, Functional, and Imaging Data.Aging and disease · 2017Review
- Review
- A profile of volatile organic compounds in exhaled air as a potential non-invasive biomarker for liver cirrhosis.Scientific reports · 2016Article
- Analysis of Breath Specimens for Biomarkers of Plasmodium falciparum Infection.The Journal of infectious diseases · 2015Article
- Biomarkers of progression of chronic obstructive pulmonary disease (COPD).Journal of thoracic disease · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe electronic nose (e nose) provides distinctive breath fingerprints for selected respiratory diseases. Both reproducibility and respiratory function correlates of breath fingerprint are poorly known.
objectivesTo measure reproducibility of breath fingerprints and to assess their correlates among respiratory function indexes in elderly healthy and COPD subjects.
method25 subjects (5 COPD patients for each GOLD stage and 5 healthy controls) over 65 years underwent e-nose study through a seven sensor system and respiratory function tests at times 0, 7, and 15 days. Reproducibility of the e nose pattern was computed. The correlation between volatile organic compound (VOC) pattern and respiratory function/clinical parameters was assessed by the Spearman's rho. MEASUREMENTS AND MAIN
resultsVOC patterns were highly reproducible within healthy and GOLD 4 COPD subjects, less among GOLD 1-3 patients.VOC patterns significantly correlated with expiratory flows (Spearman's rho ranging from 0.36 for MEF25% and sensor Co-Buti-TPP, to 0.81 for FEV1% and sensor Cu-Buti-TPP p<0.001)), but not with residual volume and total lung capacity.
conclusionsVOC patterns strictly correlated with expiratory flows. Thus, e nose might conveniently be used to assess COPD severity and, likely, to study phenotypic variability. However, the suboptimal reproducibility within GOLD 1-3 patients should stimulate further research to identify more reproducible breath print patterns.
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