ArticlePloS one2012
Phylodynamics and dispersal of HRSV entails its permanence in the general population in between yearly outbreaks in children.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Infections Caused by HRSV A ON1 Are Predominant among Hospitalized Infants with Bronchiolitis in São Paulo City.BioMed research international · 2017Trial
- Epidemiology and genetic diversity of human respiratory syncytial virus in Belgium between 2011 and 2019.Virology journal · 2024Article
- Molecular characterization of respiratory syncytial viruses circulating in a paediatric cohort in Amman, Jordan.Microbial genomics · 2021Article
- Evolution of respiratory syncytial virus genotype BA in Kilifi, Kenya, 15 years on.Scientific reports · 2020Article
- Genotyping of Type A Human Respiratory Syncytial Virus Based on Direct F Gene Sequencing.Medicina (Kaunas, Lithuania) · 2019Article
- Observational
- Investigation of Respiratory Syncytial Virus Outbreak on an Adult Stem Cell Transplant Unit by Use of Whole-Genome Sequencing.Journal of clinical microbiology · 2017Article
- Recent sequence variation in probe binding site affected detection of respiratory syncytial virus group B by real-time RT-PCR.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Article
- Local evolutionary patterns of human respiratory syncytial virus derived from whole-genome sequencing.Journal of virology · 2015Article
- Article
- Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year.International journal of pediatric otorhinolaryngology · 2014Article
- Examining strain diversity and phylogeography in relation to an unusual epidemic pattern of respiratory syncytial virus (RSV) in a long-term refugee camp in Kenya.BMC infectious diseases · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman respiratory syncytial virus (HRSV) is one of the major etiologic agents of respiratory tract infections among children worldwide. METHODOLOGY/PRINCIPAL
findingsHere through a comprehensive analysis of the two major HRSV groups A and B (n=1983) which comprise of several genotypes, we present a complex pattern of population dynamics of HRSV over a time period of 50 years (1956-2006). Circulation pattern of HRSV revealed a series of expansions and fluctuations of co-circulating lineages with a predominance of HRSVA. Positively selected amino acid substitutions of the G glycoprotein occurred upon population growth of GB3 with a 60-nucleotide insertion (GB3 Insert), while other genotypes acquired substitutions upon both population growth and decrease, thus possibly reflecting a role for immune selected epitopes in linkage to the traced substitution sites that may have important relevance for vaccine design. Analysis evidenced the co-circulation and predominance of distinct HRSV genotypes in Brazil and suggested a year-round presence of the virus. In Brazil, GA2 and GA5 were the main culprits of HRSV outbreaks until recently, when the GB3 Insert became highly prevalent. Using Bayesian methods, we determined the dispersal patterns of genotypes through several inferred migratory routes. CONCLUSIONS/SIGNIFICANCE: Genotypes spread across continents and between neighboring areas. Crucially, genotypes also remained at any given region for extended periods, independent of seasonal outbreaks possibly maintained by re-infecting the general population.
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