ArticleJournal of virology2013
High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Tracking DNA-based antigen-specific T cell receptors during progression to type 1 diabetes.Science advances · 2023Article
- Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy.International journal of molecular sciences · 2020Review
- Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors.BMC immunology · 2019Article
- RNA sequencing identifies clonal structure of T-cell repertoires in patients with adult T-cell leukemia/lymphoma.NPJ genomic medicine · 2019Article
- powerTCR: A model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire.PLoS computational biology · 2018Article
- Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire.Nature genetics · 2017Article
- Coinfection with Human Cytomegalovirus Genetic Variants in Transplant Recipients and Its Impact on Antiviral T Cell Immune Reconstitution.Journal of virology · 2016Article
- Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics.Immunology and cell biology · 2015Article
- CTLA4 blockade broadens the peripheral T-cell receptor repertoire.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains.Protein & cell · 2014Article
- Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood.Frontiers in immunology · 2014Article
- Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas.The Journal of pathology · 2013Article
- Immune parameters to consider when choosing T-cell receptors for therapy.Frontiers in immunology · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.