Evidence map›Paper›PMID 23077285›Full record

ArticleAmerican journal of epidemiology2012

On the reciprocal association between loneliness and subjective well-being.

Tyler J VanderWeele, Louise C Hawkley, John T Cacioppo

Abstract read
In one paragraph

Article in American journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Loneliness and the onset of new mental health problems in the general population.Social psychiatry and psychiatric epidemiology · 2022
    Pooled it
  2. Trial
  3. Trial
  4. Perceived connectedness during the perinatal period: Implications for parent and child well-being.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2026
    Review
  5. Article
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  11. Social Isolation and Subjective Well-Being Among Older Adults: A Longitudinal Examination by Race/Ethnicity and Gender.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  12. "Kinlessness," Social Connectedness, and Subjective Well-Being in Europe.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  13. The Loneliness of the Odd One Out: How Deviations From Social Norms Can Help Explain Loneliness Across Cultures.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025
    Article
  14. Article
  15. Multiple social factors are associated with wellbeing when accounting for shared genetic and environmental confounding.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tyler J VanderWeeleDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA. tvanderw@hsph.harvard.edu
Louise C Hawkley
John T Cacioppo

Funding

TRANSLATIONAL RESEARCH UNIVERSITY OF CHICAGO: CLINICAL TRIALSUL1RR024999 · NCRR · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2007 to 2011
$25.3M
THE SOCIAL ENVIRONMENT, LONELINESS, STRESS AND HEALTHP01AG018911 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, JOHN T. · 2001 to 2007
$8.0M
The Integrative Social Relations, Health and Aging ProjectR01AG034052 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, JOHN T. · 2008 to 2012
$3.8M
Social Regulation of Gene Expression, SupplementR37AG033590 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, JOHN T. · 2010 to 2017
$3.5M
Theory and methods for sufficient cause interactionsR01ES017876 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI VANDERWEELE, TYLER · 2010 to 2014
$1.2M
Social Regulation of Gene ExpressionR01AG033590 · NIA · UNIVERSITY OF CHICAGO · PI CACIOPPO, STEPHANIE · 2018 to 2019
$720k
Bounds for direct and indirect effects with application to perinatal epidemiologyR03HD060696 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI VANDERWEELE, TYLER · 2010 to 2011
$169k
Intramural NIH HHS Z99 RG999999NCRR NIH HHS UL1 RR024999NCRR NIH HHS UL1RR024999NIA NIH HHS AG033590NIA NIH HHS P01 AG018911NIA NIH HHS R01 AG034052NIA NIH HHS R37 AG033590NICHD NIH HHS R03 HD060696NICHD NIH HHS R03HD060696NIEHS NIH HHS R01 ES017876NIEHS NIH HHS R01ES017876
6 · The paper itself

Abstract

Loneliness has been shown to longitudinally predict subjective well-being. The authors used data from a longitudinal population-based study (2002-2006) of non-Hispanic white, African-American, and nonblack Latino-American persons born between 1935 and 1952 and living in Cook County, Illinois. They applied marginal structural models for time-varying exposures to examine the magnitude and persistence of the effects of loneliness on subjective well-being and of subjective well-being on loneliness. Their results indicate that, if interventions on loneliness were made 1 and 2 years prior to assessing final subjective well-being, then only the intervention 1 year prior would have an effect (standardized effect = -0.29). In contrast, increases in subjective well-being 1 year prior (standardized effect = -0.26) and 2 years prior (standardized effect = -0.13) to assessing final loneliness would both have an effect on an individual's final loneliness. These effects persist even after control is made for depressive symptoms, social support, and psychiatric conditions and medications as time-varying confounders. Results from this study indicate an asymmetrical and persistent feedback of fairly substantial magnitude between loneliness and subjective well-being. Mechanisms responsible for the asymmetry are discussed. Developing interventions for loneliness and subjective well-being could have substantial psychological and health benefits.

Indexed as

Health StatusLonelinessAgedBlack or African AmericanDepressionFemaleHispanic or LatinoHumansIllinoisLongitudinal StudiesMaleMiddle AgedPersonal SatisfactionRacial GroupsSocial SupportSocioeconomic Factors

Identifiers

PMID23077285
PMCPMC3571255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.