ArticleProceedings of the National Academy of Sciences of the United States of America2012
The T-cell receptor is not hardwired to engage MHC ligands.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Evolutionary trade-offs constraining the MHC gene expansion: beyond simple TCR depletion model.Frontiers in immunology · 2023Article
- MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction.Frontiers in immunology · 2022Review
- Nanoscale Colocalization of NK Cell Activating and Inhibitory Receptors Controls Signal Integration.Frontiers in immunology · 2022Article
- Why the Outcome of Anti-Tumor Immune Responses is Heterogeneous: A Novel Idea in the Context of Immunological Heterogeneity in Cancers.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Article
- MHC Restriction: Where Are We Now?Viral immunology · 2020Article
- Understanding the drivers of MHC restriction of T cell receptors.Nature reviews. Immunology · 2018Review
- T Cell Receptor Alpha Chain Genes in the Teleost Ballan WrasseFrontiers in immunology · 2018Article
- αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivity.Scientific reports · 2016Article
- Genetic variation in MHC proteins is associated with T cell receptor expression biases.Nature genetics · 2016Article
- Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Revealing the TCR bias for MHC molecules.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The T cell antigen receptor: the Swiss army knife of the immune system.Clinical and experimental immunology · 2015Review
- Lymphocyte repertoire selection and intracellular self/non-self-discrimination: historical overview.Immunology and cell biology · 2015Review
- An old Twist in HLA-A: CDR3α Hook up at an R65-joint.Frontiers in immunology · 2015Review
- T cell receptor bias for MHC: co-evolution or co-receptors?Cellular and molecular life sciences : CMLS · 2014Review
- Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.The Journal of biological chemistry · 2014Article
- A novel T cell subset with trans-rearranged Vγ-Cβ TCRs shows Vβ expression is dispensable for lineage choice and MHC restriction.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.Journal of molecular biology · 2013Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
The bias of αβ T cells for MHC ligands has been proposed to be intrinsic to the T-cell receptor (TCR). Equally, the CD4 and CD8 coreceptors contribute to ligand restriction by colocalizing Lck with the TCR when MHC ligands are engaged. To determine the importance of intrinsic ligand bias, the germ-line TCR complementarity determining regions were extensively diversified in vivo. We show that engagement with MHC ligands during thymocyte selection and peripheral T-cell activation imposes remarkably little constraint over TCR structure. Such versatility is more consistent with an opportunist, rather than a predetermined, mode of interface formation. This hypothesis was experimentally confirmed by expressing a hybrid TCR containing TCR-γ chain germ-line complementarity determining regions, which engaged efficiently with MHC ligands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.