ArticleThe Journal of nutrition2012
This kinetic, bioavailability, and metabolism study of RRR-α-tocopherol in healthy adults suggests lower intake requirements than previous estimates.
Article in The Journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Vitamin E absorption and kinetics in healthy women, as modulated by food and by fat, studied using 2 deuterium-labeled α-tocopherols in a 3-phase crossover design.The American journal of clinical nutrition · 2019Trial
- Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.The American journal of clinical nutrition · 2017Trial
- α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial.The American journal of clinical nutrition · 2015Trial
- An overview of international reference values for vitamin E intake - similarities and differences in derivation.European journal of nutrition · 2026Review
- Co-Ingestion Timing, Rather than Food Matrix or Dose, Determines α-Tocopherol Bioavailability from Intrinsically Labeled Spinach in Healthy Adults: A Crossover Pharmacokinetic Study.Antioxidants (Basel, Switzerland) · 2026Article
- Associations between Brain Alpha-Tocopherol Stereoisomer Profile and Hallmarks of Brain Aging in Centenarians.Antioxidants (Basel, Switzerland) · 2024Article
- Scientific opinion on the tolerable upper intake level for vitamin E.EFSA journal. European Food Safety Authority · 2024Article
- Separation of Lipoproteins for Quantitative Analysis ofInternational journal of molecular sciences · 2024Article
- The First Physiologically Based Pharmacokinetic (PBPK) Model for an Oral Vaccine Using Alpha-Tocopherol as an Adjuvant.Pharmaceutics · 2023Article
- Novel Lipids to Regulate Obesity and Brain Function: Comparing Available Evidence and Insights from QSAR In Silico Models.Foods (Basel, Switzerland) · 2023Review
- Reflections of an aging free radical.Free radical biology & medicine · 2020Review
- Delineation of the Individual Effects of Vitamin E Isoforms on Early Life Incident Wheezing.The Journal of pediatrics · 2019Article
- A report of activities related to the Dietary Reference Intakes from the Joint Canada-US Dietary Reference Intakes Working Group.The American journal of clinical nutrition · 2019Article
- The Ability of Exercise-Associated Oxidative Stress to Trigger Redox-Sensitive Signalling Responses.Antioxidants (Basel, Switzerland) · 2017Review
- Skin aging: are adipocytes the next target?Aging · 2016Review
- Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol.EFSA journal. European Food Safety Authority · 2015Article
- α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults.The American journal of clinical nutrition · 2015Article
- Can supplementation with vitamin C and E alter physiological adaptations to strength training?BMC sports science, medicine & rehabilitation · 2014Article
- Influence of prematurity and birth weight on the concentration of α-tocopherol in colostrum milk.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2013Article
- Mechanisms for the prevention of vitamin E excess.Journal of lipid research · 2013Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Kinetic models enable nutrient needs and kinetic behaviors to be quantified and provide mechanistic insights into metabolism. Therefore, we modeled and quantified the kinetics, bioavailability, and metabolism of RRR-α-tocopherol in 12 healthy adults. Six men and 6 women, aged 27 ± 6 y, each ingested 1.81 nmol of [5(-14)CH(3)]-(2R, 4'R, 8'R)-α-tocopherol; each dose had 3.70 kBq of (14)C. Complete collections of urine and feces were made over the first 21 d from dosing. Serial blood samples were drawn over the first 70 d from dosing. All specimens were analyzed for RRR-α-tocopherol. Specimens were also analyzed for (14)C using accelerator MS. From these data, we modeled and quantified the kinetics of RRR-α-tocopherol in vivo in humans. The model had 11 compartments, 3 delay compartments, and reservoirs for urine and feces. Bioavailability of RRR-α-tocopherol was 81 ± 1%. The model estimated residence time and half-life of the slowest turning-over compartment of α-tocopherol (adipose tissue) at 499 ± 702 d and 184 ± 48 d, respectively. The total body store of RRR-α-tocopherol was 25,900 ± 6=220 μmol (11 ± 3 g) and we calculated the adipose tissue level to be 1.53 μmol/g (657 μg/g). We found that a daily intake of 9.2 μmol (4 mg) of RRR-α-tocopherol maintained plasma RRR-α-tocopherol concentrations at 23 μmol/L. These findings suggest that the dietary requirement for vitamin E may be less than that currently recommended and these results will be important for future updates of intake recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.