ArticleJournal of cell science2012
Nuclear Na+/K+-ATPase plays an active role in nucleoplasmic Ca2+ homeostasis.
Article in Journal of cell science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Inflammatory Co-Regulation of Voltage-Gated Sodium Channels and Na,K-ATPase in Metastatic Breast Cancer.International journal of molecular sciences · 2025Article
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- Immune Cell Migration Models Synergize Nuclear Piston, Uropod, and Microenvironment into Hydraulic Cell Engine.bioRxiv : the preprint server for biology · 2025Article
- The Impact of Salinity on Crop Yields and the Confrontational Behavior of Transcriptional Regulators, Nanoparticles, and Antioxidant Defensive Mechanisms under Stressful Conditions: A Review.International journal of molecular sciences · 2024Review
- Gangliosides in Neurodegenerative Diseases.Advances in neurobiology · 2023Article
- Displacement of Native FXYD Protein From NaFrontiers in oncology · 2022Article
- Spermine protects aluminium chloride and iron-induced neurotoxicity in rat model of Alzheimer's disease via attenuation of tau phosphorylation, Amyloid-β (1-42) and NF-κB pathway.Inflammopharmacology · 2021Article
- Allicin ameliorates aluminium- and copper-induced cognitive dysfunction in Wistar rats: relevance to neuro-inflammation, neurotransmitters and AβJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021Article
- The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle.eLife · 2021Article
- Autosis: A New Target to Prevent Cell Death.JACC. Basic to translational science · 2020Review
- Involvement of the Actin Machinery in Programmed Cell Death.Frontiers in cell and developmental biology · 2020Review
- Transporter-Mediated Subcellular Distribution in the Metabolism and Signaling of Jasmonates.Frontiers in plant science · 2019Article
- NaCell death discovery · 2018Article
- Na+ extrusion from the cytosol and tissue-specific Na+ sequestration in roots confer differential salt stress tolerance between durum and bread wheat.Journal of experimental botany · 2018Article
- Application of Spectral Phasor analysis to sodium microenvironments in myoblast progenitor cells.PloS one · 2018Article
- Bioelectrical regulation of cell cycle and the planarian model system.Biochimica et biophysica acta · 2015Review
- Autosis and autophagic cell death: the dark side of autophagy.Cell death and differentiation · 2015Review
- Minimization of extracellular space as a driving force in prokaryote association and the origin of eukaryotes.Biology direct · 2014Article
- Gene-expression profile and localization of Na+/K(+)-ATPase in rat enamel organ cells.European journal of oral sciences · 2014Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Na(+)/K(+)-ATPase, an integral membrane protein, has been studied for over a half century with respect to its transporter function in the plasma membrane, where it expels three Na(+) ions from the cell in exchange for two K(+) ions. In this study, we demonstrate a functioning Na(+)/K(+)-ATPase within HEK293 cell nuclei. This subcellular localization was confirmed by western blotting, ouabain-sensitive ATPase activity of the nuclear membrane fraction, immunocytochemistry and delivery of fluorescently tagged Na(+)/K(+)-ATPase α- and β-subunits. In addition, we observed an overlap between nuclear Na(+)/K(+)-ATPase and Na/Ca-exchanger (NCX) when nuclei were immunostained with commercially available Na(+)/K(+)-ATPase and NCX antibodies, suggesting a concerted physiological coupling between these transporters. In keeping with this, we observed an ATP-dependent, strophanthidin-sensitive Na(+) flux into the nuclear envelope (NE) lumen loaded with the Na-sensitive dye, CoroNa-Green. Analogous experiments using Fluo-5N, a low affinity Ca(2+) indicator, demonstrated a similar ATP-dependent and strophanthidin-sensitive Ca(2+) flux into the NE lumen. Our results reveal an intracellular physiological role for the coordinated efforts of the Na(+)/K(+)-ATPase and NCX to actively remove Ca(2+) from the nucleoplasm into the NE lumen (i.e. the nucleoplasmic reticulum).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.