ArticleAmerican journal of physiology. Renal physiology2012
Iodinated contrast media cause endothelial damage leading to vasoconstriction of human and rat vasa recta.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 74 citations in OpenAlex.
- Cellular Mechanisms Underlying Endothelial and Histopathological Alterations Induced by Cerebral Angiography.Journal of clinical medicine · 2026Review
- Late-onset Total Necrosis in Deep Inferior Epigastric Perforator Flap after Contrast Enhanced Computed Tomography.Plastic and reconstructive surgery. Global open · 2024Article
- High-mobility group box 1 and its related receptors: potential therapeutic targets for contrast-induced acute kidney injury.International urology and nephrology · 2024Review
- A new parameter in predicting contrast-induced nephropathy: Osaka prognostic score.Revista da Associacao Medica Brasileira (1992) · 2024Article
- The Potential Biotherapeutic Targets of Contrast-Induced Acute Kidney Injury.International journal of molecular sciences · 2023Review
- Prevention of contrast-associated acute kidney injury in an era of increasingly complex interventional procedures.Frontiers in medicine · 2023Review
- The Pathophysiology and the Management of Radiocontrast-Induced Nephropathy.Diagnostics (Basel, Switzerland) · 2022Review
- Recent advances in molecular mechanisms of acute kidney injury in patients with diabetes mellitus.Frontiers in endocrinology · 2022Review
- A Novel Prediction Model of Acute Kidney Injury Based on Combined Blood Variables in STEMI.JACC. Asia · 2021Article
- Combined evaluation of plasma B-type natriuretic peptide and urinary liver-type fatty acid-binding protein/creatinine ratio is related to worsening renal function in patients undergoing elective percutaneous coronary intervention.Clinical and experimental nephrology · 2021Observational
- Computed Tomography Angiography (CTA) before Reconstructive Jaw Surgery Using Fibula Free Flap: Retrospective Analysis of Vascular Architecture.Diagnostics (Basel, Switzerland) · 2021Article
- Rationale and Design of Assessing the Effectiveness of Short-Term Low-Dose Lithium Therapy in Averting Cardiac Surgery-Associated Acute Kidney Injury: A Randomized, Double Blinded, Placebo Controlled Pilot Trial.Frontiers in medicine · 2021Article
- Ferrotoxicity and Its Amelioration by Calcitriol in Cultured Renal Cells.Analytical cellular pathology (Amsterdam) · 2021Article
- Ferrotoxicity and its amelioration by endogenous vitamin D in experimental acute kidney injury.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- D-4F Ameliorates Contrast Media-Induced Oxidative Injuries in Endothelial Cells via the AMPK/PKC Pathway.Frontiers in pharmacology · 2020Article
- The pathogenesis of iodide mumps: A case report.Medicine · 2017Article
- AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms.Kidney international · 2017Review
- Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography.Bioconjugate chemistry · 2017Review
- Understanding and preventing contrast-induced acute kidney injury.Nature reviews. Nephrology · 2017Review
- Elevation of urinary liver-type fatty acid binding protein after cardiac catheterization related to cardiovascular events.International journal of nephrology and renovascular disease · 2015Article
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8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contrast-induced acute kidney injury is an important clinical event with a worldwide increasing number of cases. Medullary hypoperfusion and hypoxia due to constriction of vasa recta are main factors in the pathophysiology of acute kidney injury. However, the mechanism of contrast media (CM)-induced vessel constriction is not known. We tested the hypothesis that vasa recta constriction is a consequence of endothelial dysfunction due to the cytotoxicity of CM. Human and rat descending vasa recta (DVR) were isolated and perfused with CM, and the luminal diameter was analyzed. For morphological analysis of the endothelium, renal arteries were CM perfused and then processed for electron microscopy. Transcellular electrical resistance was used to estimate CM-induced changes in the permeability of human umbilical vein endothelial cell (HUVEC) layers. Perfusion with CM constricted human and rat DRV (to 54.3 and 50.9% of initial diameter, respectively). This was blunted by adrenomedullin (77.7 and 77.1%, respectively). The ANG II response was enhanced by CM in rat DVR (reduction to 15.6 and 35.0% of initial diameter, respectively). Adrenomedullin blunted this effect (67.5%). CM led to endothelial damage of renal arteries characterized by a ragged surface, with sharply protruding intimal folds, spindle-like shape, and bulging in the lumen. These phenomena were reduced by adrenomedullin. The permeability of HUVEC cell layers was increased by CM, and this went along with increased myosin light chain phosporylation. Again, adremonedullin reduced the CM effect. Our study suggests that the constrictor effect of CM on the renal medullary microvasculature is a consequence of endothelial cell damage and the resulting endothelial dysfunction.
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