ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
The retinoblastoma protein is essential for survival of postmitotic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Rb substantially compensates for the double loss of p130 and p107 in adult but not embryonic neural stem cell lineages.Cell death & disease · 2025Article
- Rb deficiency, neuronal survival and neurodegeneration: In search of the perfect mouse model.Current research in neurobiology · 2023Review
- METTLing in Stem Cell and Cancer Biology.Stem cell reviews and reports · 2023Review
- Evidence of cell cycle re-entry in post-mitotic, terminally differentiated feline neurons.Histochemistry and cell biology · 2022Article
- Article
- Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development.Cell death & disease · 2021Article
- Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.Frontiers in cell and developmental biology · 2021Article
- Cell Cycle Proteins as Key Regulators of Postmitotic Cell Death.The Yale journal of biology and medicine · 2019Review
- Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons.Frontiers in cellular neuroscience · 2019Review
- "Till Death Do Us Part": A Potential Irreversible Link Between Aberrant Cell Cycle Control and Neurodegeneration in the Adult Olfactory Bulb.Frontiers in neuroscience · 2018Review
- The loss of the kinases SadA and SadB results in early neuronal apoptosis and a reduced number of progenitors.PloS one · 2018Article
- RB: An essential player in adult neurogenesis.Neurogenesis (Austin, Tex.) · 2017Article
- Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex.Regenerative therapy · 2016Review
- Role of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb.Scientific reports · 2016Article
- Role of Rb during Neurogenesis and Axonal Guidance in the Developing Olfactory System.Frontiers in molecular neuroscience · 2016Article
- Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry.Cell death and differentiation · 2015Article
- RB in DNA repair.Oncotarget · 2015Article
- Induction of protein deletion through in utero electroporation to define deficits in neuronal migration in transgenic models.Journal of visualized experiments : JoVE · 2015Article
- Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner ear.Frontiers in cellular neuroscience · 2015Article
- Distinct chronology of neuronal cell cycle re-entry and tau pathology in the 3xTg-AD mouse model and Alzheimer's disease patients.Journal of Alzheimer's disease : JAD · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The retinoblastoma protein (Rb) family members are essential regulators of cell cycle progression, principally through regulation of the E2f transcription factors. Growing evidence indicates that abnormal cell cycle signals can participate in neuronal death. In this regard, the role of Rb (p105) itself has been controversial. Germline Rb deletion leads to massive neuronal loss, but initial reports argue that death is non-cell autonomous. To more definitively resolve this question, we generated acute murine knock-out models of Rb in terminally differentiated neurons in vitro and in vivo. Surprisingly, we report that acute inactivation of Rb in postmitotic neurons results in ectopic cell cycle protein expression and neuronal loss without concurrent induction of classical E2f-mediated apoptotic genes, such as Apaf1 or Puma. These results suggest that terminally differentiated neurons require Rb for continuous cell cycle repression and survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.