ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Integration of taste and calorie sensing in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 107 citations in OpenAlex.
- Insulin receptor signaling in gustatory cells suppresses sugar taste sensitivity and feeding iniScience · 2026Article
- Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis.Nature metabolism · 2026Article
- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
- Sensory regulation of meal sorting in Aedes aegypti mosquitoes.Scientific reports · 2024Article
- Preference of position in the proximity of various sugars revealed by location analysis of Drosophila melanogaster.Scientific reports · 2024Article
- Tastant-receptor interactions: insights from the fruit fly.Frontiers in nutrition · 2024Review
- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
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- Sleep benefits different stages of memory inFrontiers in physiology · 2023Review
- Enhanced olfactory memory detection in trap-design Y-mazes allows the study of imperceptible memory traces inLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Consolidation of Sleep-Dependent Appetitive Memory Is Mediated by a Sweet-Sensing Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive inScience advances · 2021Article
- Sex determination geneeLife · 2021Article
- Assessing the cognitive status of Drosophila by the value-based feeding decision.NPJ aging and mechanisms of disease · 2021Article
- Article
- A closed-loop optogenetic screen for neurons controlling feeding in Drosophila.G3 (Bethesda, Md.) · 2021Article
- Genetic manipulation of insulin/insulin-like growth factor signaling pathway activity has sex-biased effects on Drosophila body size.G3 (Bethesda, Md.) · 2021Article
- Article
- The Panopticon-Assessing the Effect of Starvation on Prolonged Fly Activity and Place Preference.Frontiers in behavioral neuroscience · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Animals use gustatory information to assess the suitability of potential food sources and make critical decisions on what to consume. For example, the taste of sugar generally signals a potent dietary source of carbohydrates. However, the intensity of the sensory response to a particular sugar, or "sweetness," is not always a faithful reporter of its nutritional value, and recent evidence suggests that animals can sense the caloric content of food independently of taste. Here, we demonstrate that the vinegar fly Drosophila melanogaster uses both taste and calorie sensing to determine feeding choices, and that the relative contribution of each changes over time. Using the capillary feeder assay, we allowed flies to choose between sources of sugars that varied in their ratio of sweetness to caloric value. We found that flies initially consume sugars according to taste. However, over several hours their preference shifts toward the food source with higher caloric content. This behavioral shift occurs more rapidly following food deprivation and is modulated by cAMP and insulin signaling within neurons. Our results are consistent with the existence of a taste-independent calorie sensor in flies, and suggest that calorie-based reward modifies long-term feeding preferences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.