Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Prefrontally driven downregulation of neural synchrony mediates goal-directed forgetting.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 75 citations in OpenAlex.
- Human memory retrieval and inhibitory control in the brain: beyond correlational evidence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Association of neuroimaging measures with facial emotional processing in healthy adults: a task fMRI study.Social cognitive and affective neuroscience · 2024Article
- Observing the suppression of individual aversive memories from conscious awareness.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Article
- Obliviate! Reviewing Neural Fundamentals of Intentional Forgetting from a Meta-Analytic Perspective.Biomedicines · 2022Review
- Compensatory mechanism of attention-deficit/hyperactivity disorder recovery in resting state alpha rhythms.Frontiers in computational neuroscience · 2022Article
- An engram of intentionally forgotten information.Nature communications · 2021Article
- List-method directed forgetting: Do critical findings generalize from short to long retention intervals?Memory & cognition · 2021Article
- The Mechanisms Underlying Interference and Inhibition: A Review of Current Behavioral and Neuroimaging Research.Brain sciences · 2021Review
- Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.PLoS biology · 2021Article
- Forgetting Unwanted Memories: Active Forgetting and Implications for the Development of Psychological Disorders.Journal of personalized medicine · 2021Review
- Stress Impairs Intentional Memory Control through Altered Theta Oscillations in Lateral Parietal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- EEG Correlates of Involuntary Cognitions in the Reflexive Imagery Task.Frontiers in psychology · 2020Article
- Probing the causal involvement of dlPFC in directed forgetting using rTMS-A replication study.PloS one · 2020Article
- Does Amount of Pre-cue Encoding Modulate Selective List Method Directed Forgetting?Frontiers in psychology · 2020Article
- Testing enhances motor practice.Memory & cognition · 2019Article
- Preventing a Thought from Coming to Mind Elicits Increased Right Frontal Beta Just as Stopping Action Does.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- The Forward Effect of Testing: Behavioral Evidence for the Reset-of-Encoding Hypothesis Using Serial Position Analysis.Frontiers in psychology · 2018Article
- Extinction of Conditioned Fear in Adolescents and Adults: A Human fMRI Study.Frontiers in human neuroscience · 2017Article
- Long-Term Memory Updating: The Reset-of-Encoding Hypothesis in List-Method Directed Forgetting.Frontiers in psychology · 2017Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural synchronization between distant cell assemblies is crucial for the formation of new memories. To date, however, it remains unclear whether higher-order brain regions can adaptively regulate neural synchrony to control memory processing in humans. We explored this question in two experiments using a voluntary forgetting task. In the first experiment, we simultaneously recorded electroencephalography along with fMRI. The results show that a reduction in neural synchrony goes hand-in-hand with a BOLD signal increase in the left dorsolateral prefrontal cortex (dlPFC) when participants are cued to forget previously studied information. In the second experiment, we directly stimulated the left dlPFC with repetitive transcranial magnetic stimulation during the same task, and show that such stimulation specifically boosts the behavioral forgetting effect and induces a reduction in neural synchrony. These results suggest that prefrontally driven downregulation of long-range neural synchronization mediates goal-directed forgetting of long-term memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.