ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Dynamic reorganization of digit representations in somatosensory cortex of nonhuman primates after spinal cord injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Characterizing Evoked Movement Patterns and Connectivity in Sensorimotor Cortex After Sensory Loss in Squirrel Monkeys.The Journal of comparative neurology · 2025Article
- Relationships Between Intra-Spinal Resting-State Functional Connectivity and Electrophysiology Following Spinal Cord Injury.Human brain mapping · 2025Article
- AI-assisted 3D analysis of grasping and reaching behavior of squirrel monkeys during recovery from cervical spinal cord injury.Behavioural brain research · 2025Article
- Differential Recovery of Submodality Touch Neurons and Interareal Communication in Sensory Input-Deprived Area 3b and S2 Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Malleability of the cortical hand map following a finger nerve block.Science advances · 2022Article
- Article
- Longitudinal fMRI measures of cortical reactivation and hand use with and without training after sensory loss in primates.NeuroImage · 2021Article
- Longitudinal changes in DTI parameters of specific spinal white matter tracts correlate with behavior following spinal cord injury in monkeys.Scientific reports · 2020Article
- Reorganization of Higher-Order Somatosensory Cortex After Sensory Loss from Hand in Squirrel Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Spatiotemporal trajectories of quantitative magnetization transfer measurements in injured spinal cord using simplified acquisitions.NeuroImage. Clinical · 2019Article
- MRI evaluation of regional and longitudinal changes in Z-spectra of injured spinal cord of monkeys.Magnetic resonance in medicine · 2018Article
- Cortical Representation of Pain and Touch: Evidence from Combined Functional Neuroimaging and Electrophysiology in Non-human Primates.Neuroscience bulletin · 2018Review
- Non-concomitant cortical structural and functional alterations in sensorimotor areas following incomplete spinal cord injury.Neural regeneration research · 2017Article
- Correlated Disruption of Resting-State fMRI, LFP, and Spike Connectivity between Area 3b and S2 following Spinal Cord Injury in Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Biophysical and neural basis of resting state functional connectivity: Evidence from non-human primates.Magnetic resonance imaging · 2017Review
- Effects of isoflurane anesthesia on resting-state fMRI signals and functional connectivity within primary somatosensory cortex of monkeys.Brain and behavior · 2016Article
- Spatiotemporal trajectories of reactivation of somatosensory cortex by direct and secondary pathways after dorsal column lesions in squirrel monkeys.NeuroImage · 2016Article
- Intracortical connections are altered after long-standing deprivation of dorsal column inputs in the hand region of area 3b in squirrel monkeys.The Journal of comparative neurology · 2016Article
- Longitudinal assessment of spinal cord injuries in nonhuman primates with quantitative magnetization transfer.Magnetic resonance in medicine · 2016Article
- Plasticity and Recovery After Dorsal Column Spinal Cord Injury in Nonhuman Primates.Journal of experimental neuroscience · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Somatosensory cortices of adult primates reactivate over time after sensory loss. The time course and the neural mechanisms underlying the cortical reactivation are not well understood. Here we report that longitudinal high-resolution functional magnetic resonance imaging (fMRI) studies on anesthetized squirrel monkeys revealed dynamic reorganizations of digit activations in area 3b, within 2 months after severely disrupting afferent inputs by dorsal column section. We found that digit regions in which inputs were severely disrupted exhibited fMRI tactile responses. Reorganization was characterized by an early moving away phase and a late returning phase, as indicated by spatial shifts of individual digit activation centers in relation to the pre-lesion activation sites. Subsequent optical imaging studies confirmed fMRI activations, and dense microelectrode penetrations identified weak neuronal activity at the reactivated sites. Activation zones detected by fMRI and optical imaging were significantly larger in input-deprived than normal input single-digit regions and were larger than regions defined by neuronal spiking activity. This study captures the dynamic reorganization of digit representations after dorsal column lesions and reveals differences between functional imaging and microelectrode recording maps. Our observations suggest that subthreshold activity plays an important role in the reactivation of deafferented cortex and could promote behavioral recovery.
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