ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Genome-wide linkage analysis of human auditory cortical activation suggests distinct loci on chromosomes 2, 3, and 8.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease.PloS one · 2022Trial
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- Human Sensorimotor Beta Event Characteristics and Aperiodic Signal Are Highly Heritable.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Attentional modulation of interhemispheric (a)symmetry in children with developmental language disorder.Scientific reports · 2022Article
- The relationship between electrophysiological and hemodynamic measures of neural activity varies across picture naming tasks: A multimodal magnetoencephalography-functional magnetic resonance imaging study.Frontiers in neuroscience · 2022Article
- Sensory cortical and subcortical auditory neurophysiological changes predict cue-specific extinction behavior enabled by the pharmacological inhibition of an epigenetic regulator during memory formation.Brain research bulletin · 2021Article
- Associations and Heritability of Auditory Encoding, Gray Matter, and Attention in Schizophrenia.Schizophrenia bulletin · 2019Article
- Children show hemispheric differences in the basic auditory response properties.Human brain mapping · 2019Article
- Discovering heritable modes of MEG spectral power.Human brain mapping · 2019Article
- Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity.The European journal of neuroscience · 2016Article
- Article
- Analytical methods and experimental approaches for electrophysiological studies of brain oscillations.Journal of neuroscience methods · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural processes are explored through macroscopic neuroimaging and microscopic molecular measures, but the two levels remain primarily detached. The identification of direct links between the levels would facilitate use of imaging signals as probes of genetic function and, vice versa, access to molecular correlates of imaging measures. Neuroimaging patterns have been mapped for a few isolated genes, chosen based on their connection with a clinical disorder. Here we propose an approach that allows an unrestricted discovery of the genetic basis of a neuroimaging phenotype in the normal human brain. The essential components are a subject population that is composed of relatives and selection of a neuroimaging phenotype that is reproducible within an individual and similar between relatives but markedly variable across a population. Our present combined magnetoencephalography and genome-wide linkage study in 212 healthy siblings demonstrates that auditory cortical activation strength is highly heritable and, specifically in the right hemisphere, regulated oligogenically with linkages to chromosomes 2q37, 3p12, and 8q24. The identified regions delimit as candidate genes TRAPPC9, operating in neuronal differentiation, and ROBO1, regulating projections of thalamocortical axons. Identification of normal genetic variation underlying neurophysiological phenotypes offers a non-invasive platform for an in-depth, concerted capitalization of molecular and neuroimaging levels in exploring neural function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.