ArticleNeurology2012
Sex-specific differences in retinal nerve fiber layer thinning after acute optic neuritis.
Article in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Etiologic spectrum and predictors of visual acuity in non-glaucomatous optic atrophy.SAGE open medicine · 2026Article
- Sex and gender as contributors to brain pathophysiology, clinical course, and therapeutic response in multiple sclerosis.Frontiers in behavioral neuroscience · 2026Review
- Beyond the optic disc: Investigating gender-based differences in optic neuritis.World journal of clinical cases · 2025Review
- Investigating the Relationship between Telomere-Related Gene Variants and Leukocyte Telomere Length in Optic Neuritis Patients.Journal of clinical medicine · 2024Article
- Sex or Gender Reporting in Ophthalmology Clinical Trials Among US Food and Drug Administration Approvals, 1995 to 2022.JAMA ophthalmology · 2024Article
- Effectiveness of oral prednisone tapering following intravenous methylprednisolone for acute optic neuritis in multiple sclerosis.PloS one · 2023Article
- Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders.Neurology(R) neuroimmunology & neuroinflammation · 2022Review
- The changing landscape of optic neuritis: a narrative review.Journal of neurology · 2022Review
- What Can We Learn from Sex Differences in MS?Journal of personalized medicine · 2021Article
- Identification of posterior visual pathway lesions and MRI burden in people with Multiple Sclerosis.Neurosciences (Riyadh, Saudi Arabia) · 2021Review
- Bilateral retinal pathology following a first-ever clinical episode of autoimmune optic neuritis.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Using Acute Optic Neuritis Trials to Assess Neuroprotective and Remyelinating Therapies in Multiple Sclerosis.JAMA neurology · 2020Article
- Sex Hormones and Optic Nerve Disorders: A Review.Frontiers in neuroscience · 2019Review
- Analysis of multiple sclerosis patients with electrophysiological and structural tests.International ophthalmology · 2017Article
- Longitudinal evidence for anterograde trans-synaptic degeneration after optic neuritis.Brain : a journal of neurology · 2016Article
- Retinal nerve fiber layer sector-specific compromise in relapsing and remitting multiple sclerosis.eNeurologicalSci · 2015Article
- [Optic neuropathy after retrobulbar neuritis in multiple sclerosis: are optical coherence tomography and magnetic resonance imaging useful and necessary follow-up parameters?].Der Nervenarzt · 2015Observational
- Vision and vision-related outcome measures in multiple sclerosis.Brain : a journal of neurology · 2015Review
- Retinal ganglion cell loss is associated with multimodal visual dysfunction following demyelinating optic neuritis.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe primary objective of this study was to explore the potential influence of gender on recovery from optic neuritis (ON) by determining whether differences in retinal nerve fiber layer (RNFL) thickness can be detected between men and women 6 months after an ON event.
methodsIn this prospective cohort study, 39 men and 105 women with acute ON underwent repeat visual and optical coherence tomography (OCT) testing. The main outcome measures were change in RNFL measurements for male and female patients 6 months after ON.
resultsMen were older (mean age = 39 years) than women (35 years) (p = 0.05) in this study, and more men (62%) than women (41%) had a diagnosis of relapsing-remitting multiple sclerosis (MS) (p = 0.02). Because age and MS subtype were 2 significant covariates, both variables were controlled for in multiple regression analyses. Other covariates controlled for in the multivariate regression included disease duration (years), use of disease-modifying therapy (yes/no), and use of high-dose corticosteroids for acute ON (yes/no). After 6 months, mean RNFL values were lower in men (74 μm) than women (91 μm) (p < 0.001). Men showed more apparent change in RNFL thickness in their ON eyes from baseline to 6 months after ON than women (p = 0.003).
conclusionsThere may be differences in recovery between men and women after ON, which can be difficult to detect with conventional visual testing. Our findings raise interesting questions about the potential influence of gender in MS, which may be explored in future studies.
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