Evidence map›Paper›PMID 23076723›Full record

Trial reportJournal of neural transmission (Vienna, Austria : 1996)2013

Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer's disease: a randomized, double-blind study.

Jose M Rabey, Evgenia Dobronevsky, Sergio Aichenbaum, Ofer Gonen, Revital Gendelman Marton, Michael Khaigrekht

4 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neural transmission (Vienna, Austria : 1996), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 104 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 15 pooled it
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00814697 phase2completednot on this map

Open-label, Exploratory Study of the Efficacy of Repetitive Transcranial Magnetic Stimulation on Naming and Verbal Fluency in Patients With Alzheimer's Disease With Functional Imaging Correlates

TypeinterventionalSponsorThe New York Memory ServicesRan2008 to 2012Enrolled12ConditionsAlzheimer's Disease, Aphasia, DementiaArmsRepetitive Transcranial Magnetic Coil Stimulation (rTMS)
NCT01168245 phase1completednot on this map

Effects of a Combined TMS Stimulation and Cognitive Training in Alzheimer Patients: a Single-center, Randomized, Double-blind, Placebo-controlled Study

TypeinterventionalSponsorNeuronix LtdRan2010 to 2011Enrolled15ConditionsAlzheimer Disease, Mild to ModerateArmsSham-NICE-System, NICE-System
NCT04482179 phase1completednot on this mapstarted 2020, after this paper: background citation

A Phase II, Randomized, Blinded Study of Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for the Treatment of Chronic Aphasia - Alzheimer Disease Sub-study

TypeinterventionalSponsorUniversity of PennsylvaniaRan2020 to 2024Enrolled23ConditionsAlzheimer DiseaseArmsActive TMS, CILT, Sham TMS
NCT04866979 naunknown statusnot on this mapstarted 2021, after this paper: background citation

StimoLaMente - La Stimolazione Cerebrale Non Invasiva Applicata Alla Riabilitazione Della Malattia di Alzheimer/ StimoLaMente - Applying Non-invasive Brain Stimulation in Alzheimer's Rehabilitation

TypeinterventionalSponsorUniversità degli Studi di TrentoRan2021 to 2024Enrolled200ConditionsAlzheimer Disease, Mild Cognitive ImpairmentArmsExperimental: Continuous TBS (cTBS), Intermittent TBS (iTBS), Cognitive training (CT)., Sham Stimulation (shamTBS)
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 15 syntheses or guidelines pooled it, 224 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Efficacy of intermittent theta burst stimulation (iTBS) on post-stroke cognitive impairment (PSCI): a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Neurostimulation in Alzheimer's disease: from basic research to clinical applications.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015
    Pooled it
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jose M RabeyDepartment of Neurology, Assaf Harofeh Medical Center, Zerifin 70300, Israel. JMR@asaf.health.gov.il
Evgenia Dobronevsky
Sergio Aichenbaum
Ofer Gonen
Revital Gendelman Marton
Michael Khaigrekht
Assaf Harofeh Medical Center · ILTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cortical excitability can be modulated using repetitive transcranial magnetic stimulation (rTMS). Previously, we showed that rTMS combined with cognitive training (rTMS-COG) has positive results in Alzheimer's disease (AD). The goal of this randomized double-blind, controlled study was to examine the safety and efficacy of rTMS-COG in AD. Fifteen AD patients received 1-h daily rTMS-COG or sham treatment (seven treated, eight placebo), five sessions/week for 6 weeks, followed by biweekly sessions for 3 months. The primary outcome was improvement of the cognitive score. The secondary outcome included improvement in the Clinical Global Impression of Change (CGIC) and Neuropsychiatric Inventory (NPI). There was an improvement in the average ADAS-cog score of 3.76 points after 6 weeks in the treatment group compared to 0.47 in the placebo group and 3.52 points after 4.5 months of treatment, compared to worsening of 0.38 in the placebo (P = 0.04 and P = 0.05, respectively). There was also an improvement in the average CGIC score of 3.57 (after 6 weeks) and 3.67 points (after 4.5 months), compared to 4.25 and 4.29 in the placebo group (mild worsening) (P = 0.05 and P = 0.05, respectively). NPI improved non-significantly. In summary, the NeuroAD system offers a novel, safe and effective therapy for improving cognitive function in AD.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAnalysis of VarianceCognitive Behavioral TherapyDouble-Blind MethodFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleNeuropsychological TestsPatient CompliancePsychiatric Status Rating ScalesTranscranial Magnetic StimulationTreatment Outcome

Identifiers

PMID23076723
OpenAlexW2102215373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.