Evidence map›Paper›PMID 23076682›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012

Atypical fractures do not have a thicker cortex.

V A Koeppen, J Schilcher, P Aspenberg

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

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17citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  3. Article
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  5. Article
  6. Sensitivity and specificity of radiographic characteristics in atypical femoral fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Factors associated with atypical femoral fracture.Rheumatology international · 2016
    Article
  13. Mandibular inferior cortical bone thickness on panoramic radiographs in patients using bisphosphonates.Oral surgery, oral medicine, oral pathology and oral radiology · 2015
    Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

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5 · Who and what money

Authors and funding

3 authors.

V A KoeppenOrthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linköping University, 581 85 Linköping, Sweden.
J Schilcher
P Aspenberg

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledAn association between atypical fractures and general cortical thickness of the femoral shaft is often suggested in the literature. Our radiographic measurements of 59 atypical and 218 ordinary fractures now exclude a difference larger than 10 % in mean femoral cortical thickness (sum of lateral and medial) with 95 % confidence.

introductionAn increased general cortical thickness in patients with fatigue fracture of the femoral shaft (atypical fractures) is commonly suggested. However, there are scarce data to support this.

methodsIn a published nationwide Swedish study, we identified by radiographic review 59 women with an atypical fracture during 2008. The femoral cortical thickness index (thickness/femoral diameter) of these women was now compared with the 218 ordinary fractures that occurred in the same region of the femur in a case-control design. The cortical thickness index 5 cm below the lesser trochanter was the primary variable.

resultsPatients with atypical fractures were younger. Without correction for age, they had a thicker cortex (i.e., higher index). However, the difference in cortical thickness disappeared after age correction. The 95 % CI excludes a group mean difference exceeding 10 % of total mean thickness. Similarly, there was no significant difference in cortical thickness between patients with or without bisphosphonate treatment or between the ipsi- and contralateral femurs in patients with an atypical fracture.

conclusionThe concept of a generally increased cortical thickness in patients with atypical fractures should be reconsidered.

Indexed as

AgedAged, 80 and overAge FactorsBone Density Conservation AgentsCase-Control StudiesDiaphysesDiphosphonatesFemaleFemoral FracturesFractures, StressHumansMiddle AgedOsteoporosis, PostmenopausalOsteoporotic FracturesRadiographyBone Density Conservation AgentsDiphosphonates

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.