ReviewNeurochemical research2013
Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance.
Review in Neurochemical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Rhythmic patterns in microglial cells within the circadian pineal gland from male rats.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies.Cancer cell · 2026Article
- An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma.Genes & development · 2025Article
- Embryonic LTR retrotransposons supply promoter modules to somatic tissues.Genome research · 2021Article
- Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland.Journal of pineal research · 2020Article
- The Lhx4 homeobox transcript in the rat pineal gland: Adrenergic regulation and impact on transcripts encoding melatonin-synthesizing enzymes.Journal of pineal research · 2020Article
- Pineal progenitors originate from a non-neural territory limited by FGF signalling.Development (Cambridge, England) · 2019Article
- Chromatin dynamics enable transcriptional rhythms in the cnidarian Nematostella vectensis.PLoS genetics · 2019Article
- Dynamic Transcriptome Analysis Reveals Potential Long Non-coding RNAs Governing Postnatal Pineal Development in Pig.Frontiers in genetics · 2019Article
- Differential response of pineal microglia to surgical versus pharmacological stimuli.The Journal of comparative neurology · 2018Article
- Rhythmic Regulation of Photoreceptor and RPE Genes Important for Vision and Genetically Associated With Severe Retinal Diseases.Investigative ophthalmology & visual science · 2018Article
- The origins of the circumventricular organs.Journal of anatomy · 2018Review
- Article
- Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors.PloS one · 2017Article
- Melatonin Synthesis: Acetylserotonin O-Methyltransferase (ASMT) Is Strongly Expressed in a Subpopulation of Pinealocytes in the Male Rat Pineal Gland.Endocrinology · 2016Article
- Cellular Basis of Pineal Gland Development: Emerging Role of Microglia as Phenotype Regulator.PloS one · 2016Article
- The Lhx9 homeobox gene controls pineal gland development and prevents postnatal hydrocephalus.Brain structure & function · 2015Article
- Homeobox genes and melatonin synthesis: regulatory roles of the cone-rod homeobox transcription factor in the rodent pineal gland.BioMed research international · 2014Review
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal development consistent with the well-established role that homeobox genes play in developmental processes. However, the pineal gland appears to be unusual because strong homeobox gene expression persists in the pineal gland of the adult brain. Accordingly, in addition to developmental functions, homeobox genes appear to be key regulators in postnatal phenotype maintenance in this tissue. In this paper, we review ontogenetic and phylogenetic aspects of pineal development and recent progress in understanding the involvement of homebox genes in rodent pineal development and adult function. A working model is proposed for understanding the sequential action of homeobox genes in controlling development and mature circadian function of the mammalian pinealocyte based on knowledge from detailed developmental and daily gene expression analyses in rats, the pineal phenotypes of homebox gene-deficient mice and studies on development of the retinal photoreceptor; the pinealocyte and retinal photoreceptor share features not seen in other tissues and are likely to have evolved from the same ancestral photodetector cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.