ReviewMolecular biology reports2013
Involvement of β-arrestins in cancer progression.
Review in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis.Carcinogenesis · 2021Article
- Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?Frontiers in pharmacology · 2020Review
- The Role of β-Arrestin1 in Esophageal Squamous Cell Carcinoma.OncoTargets and therapy · 2020Article
- Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer.British journal of cancer · 2018Article
- You're Not under Arrest: Worry-free with β-arrestin.Korean circulation journal · 2018Article
- Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.Nature communications · 2018Article
- The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review).International journal of molecular medicine · 2018Review
- COX-1/PGEScientific reports · 2017Article
- Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma.Scientific reports · 2016Article
- Loss of β-arrestin1 expression predicts unfavorable prognosis for non-small cell lung cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- β-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling.Nature communications · 2015Article
- Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms.Molecular biology of the cell · 2015Article
- β-arrestin 2 is associated with multidrug resistance in breast cancer cells through regulating MDR1 gene expression.International journal of clinical and experimental pathology · 2015Article
- The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.PloS one · 2015Article
- β-arrestin 1 Overexpression Increases Temozolomide Resistance in Human Malignant Glioma Cells.Current health sciences journalArticle
- The Effect of Β-Arrestin2 Overexpression Regarding Viability and Temozolomide Treatment in High-Grade Glioma Cells.Current health sciences journalArticle
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
β-arrestins, including β-arrestin1 and β-arrestin2, are ubiquitous cytosolic proteins which localize in the cytoplasm and plasma membrane, initially be regarded as an potential character in G protein-coupled receptors (GPCR) desensitization, sequestration, and internalization. Besides, recent many studies increasingly revealed that β-arrestins served widely as versatile adapter proteins for scaffolding many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors and downstream kinases. As we known, the biologic and clinical behaviors of many tumors are largely determined by multiple molecular signal pathways. More recently, accumulating evidences established that β-arrestins got widely involved in many cancer developmental signaling events which responsible for tumor viability and metastasis, suggesting an impressive role of β-arrestins in tumor progression. Because of the regulation and biological output of β-arrestins is so complex, the role of β-arrestins in cancer development still remains enigmatic. However, the further understanding with the clinical prognosis and oncogenic potential of β-arrestins might facilitate the identification of diagnosis biomarkers and development of drug targets in cancer. In this article, we reviewed a comprehensive summary of the β-arrestins-mediated functions in human cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.