ArticleThe journal of nutrition, health & aging2012
Frailty status and altered dynamics of circulating energy metabolism hormones after oral glucose in older women.
Article in The journal of nutrition, health & aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Inflammatory biomarkers in older adults with frailty: a systematic review and meta-analysis of cross-sectional studies.Aging clinical and experimental research · 2022Pooled it
- Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis.GeroScience · 2020Pooled it
- Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults.The journal of nutrition, health & aging · 2014Trial
- Multivariable Mendelian randomization study supports the causal effects of circulating metabolites on frailty.Aging clinical and experimental research · 2025Article
- Association between frailty and bone health in early-stage chronic kidney disease: a study from the population-based CARTaGENE cohort.Clinical kidney journal · 2025Article
- A Study of Physical Resilience and Aging (SPRING): Conceptual framework, rationale, and study design.Journal of the American Geriatrics Society · 2023Article
- Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Aging Research.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Associations between inflammation, coagulation, cardiac strain and injury, and subclinical vascular disease with frailty in older men: a cross-sectional study.BMC geriatrics · 2022Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Associations between inflammation, cardiovascular biomarkers and incident frailty: the British Regional Heart Study.Age and ageing · 2021Article
- Frailty in CKD and Transplantation.Kidney international reports · 2021Review
- The physical frailty syndrome as a transition from homeostatic symphony to cacophony.Nature aging · 2021Article
- The gut microbiome and frailty.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Standing Up for Frailty: Blood Pressure Changes Do Matter.Journal of the American Heart Association · 2020Article
- Understanding the Physiological Links Between Physical Frailty and Cognitive Decline.Aging and disease · 2020Review
- Frailty and Long-Term Post-Kidney Transplant Outcomes.Current transplantation reports · 2019Article
- Relationship of Physical Frailty to Phosphocreatine Recovery in Muscle after Mild Exercise Stress in the Oldest-Old Women.The Journal of frailty & aging · 2019Article
- Can a Link Be Found Between Physical Resilience and Frailty in Older Adults by Studying Dynamical Systems?Journal of the American Geriatrics Society · 2018Article
- The Role of Ghrelin and Ghrelin Signaling in Aging.International journal of molecular sciences · 2017Review
- Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesFrailty status is associated with altered glucose-insulin dynamics. Here, we sought to investigate whether alteration in the dynamics of other circulating energy metabolism hormones after oral glucose is associated with frailty status.
designSubstudy of older women in a prospective cohort.
settingBaltimore, Maryland.
participantsSeventy-three community-dwelling women aged 84-95 years without a diagnosis of diabetes who were enrolled in the Women's Health and Aging Study II. MEASUREMENTS: We examined stimulus-response dynamics of free fatty acids (FFA), gut- (ghrelin,GLP-1) and adipocyte-derived hormones (leptin, adiponectin, resistin), growth hormone (GH), insulin-like growth factor 1 (IGF-1), and interleukin-6 (IL-6) at 0, 30, 60, 120, and 180-minutes after a 75-g glucose challenge according to frailty status (non-frail, pre-frail, or frail).
resultsOn average, frail women had higher fasting levels of glucose-raising hormones (FFA, resistin, GH, and IL-6) and lower fasting levels of glucose-lowering hormones (ghrelin, adiponectin, GLP-1 and IGF-1) versus non-frail women but these results were not statistically significant. Frail women also had higher fasting levels of leptin with relative adiposity compared to their counterparts, suggestive of leptin-resistance. Integrated area under the curve (AUC) values for each hormone followed similar trends by frailty status. After age and BMI adjustment, frail versus non-frail women were more likely to be in the lowest tertile of fasting ghrelin levels and 120-min ghrelin levels (both p<0.05) in logistic regression analyses. No large differences were found for other hormones in adjusted models.
conclusionsOur findings suggest dysregulation of the orexigenic hormone ghrelin in the frailty syndrome. Further studies are needed to explore the role of ghrelin dysregulation in the clinical manifestation of frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.