ArticleProceedings. Biological sciences2012
Maintaining functional major histocompatibility complex diversity under inbreeding: the case of a selfing vertebrate.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Genomic structural variation rescues a classic biological invader from a population bottleneck.Science advances · 2026Article
- MHC Diversity Across Time and Space.Ecology and evolution · 2025Review
- MHC class I-α population differentiation in a commercial fish, the European sea bass (Dicentrarchus labrax).Animal genetics · 2022Article
- Depletion of MHC supertype during domestication can compromise immunocompetence.Molecular ecology · 2021Article
- Contrasting DNA methylation responses of inbred fish lines to different rearing environments.Epigenetics · 2019Article
- Divergent Allele Advantage Provides a Quantitative Model for Maintaining Alleles with a Wide Range of Intrinsic Merits.Genetics · 2019Article
- Discovery of gorilla MHC-C expressing C1 ligand for KIR.Immunogenetics · 2018Article
- Immunogenetic novelty confers a selective advantage in host-pathogen coevolution.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Immune-Related Transcriptional Responses to Parasitic Infection in a Naturally Inbred Fish: Roles of Genotype and Individual Variation.Genome biology and evolution · 2018Article
- Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen.Nature communications · 2017Article
- Genetic wealth, population health: Major histocompatibility complex variation in captive and wild ring-tailed lemurs (Ecology and evolution · 2017Article
- Retention of functional variation despite extreme genomic erosion: MHC allelic repertoires in the Lynx genus.BMC evolutionary biology · 2017Article
- Epigenetic regulation of sex ratios may explain natural variation in self-fertilization rates.Proceedings. Biological sciences · 2015Article
- Positive selection drives the evolution of a major histocompatibility complex gene in an endangered Mexican salamander species complex.Immunogenetics · 2015Article
- 454 screening of individual MHC variation in an endemic island passerine.Immunogenetics · 2015Article
- Spatially variable coevolution between a haemosporidian parasite and the MHC of a widely distributed passerine.Ecology and evolution · 2015Article
- Variation in positively selected major histocompatibility complex class I loci in rufous-collared sparrows (Zonotrichia capensis).Immunogenetics · 2014Article
- Eco-immunology of fish invasions: the role of MHC variation.Immunogenetics · 2014Article
- Evolution of MHC class I genes in the endangered loggerhead sea turtle (Caretta caretta) revealed by 454 amplicon sequencing.BMC evolutionary biology · 2013Article
- Balancing selection and the maintenance of MHC supertype variation in a selfing vertebrate.Proceedings. Biological sciences · 2013Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) genes encode proteins that present pathogen-derived antigens to T-cells, initiating the adaptive immune response in vertebrates. Although populations with low MHC diversity tend to be more susceptible to pathogens, some bottlenecked populations persist and even increase in numbers despite low MHC diversity. Thus, the relative importance of MHC diversity versus genome-wide variability for the long-term viability of populations after bottlenecks and/or under high inbreeding is controversial. We tested the hypothesis that genome-wide inbreeding (estimated using microsatellites) should be more critical than MHC diversity alone in determining pathogen resistance in the self-fertilizing fish Kryptolebias marmoratus by analysing MHC diversity and parasite loads in natural and laboratory populations with different degrees of inbreeding. Both MHC and neutral diversities were lost after several generations of selfing, but we also found evidence of parasite selection acting on MHC diversity and of non-random loss of alleles, suggesting a possible selective advantage of those individuals with functionally divergent MHC, in accordance with the hypothesis of divergent allele advantage. Moreover, we found that parasite loads were better explained by including MHC diversity in the model than by genome-wide (microsatellites) heterozygosity alone. Our results suggest that immune-related overdominance could be the key in maintaining variables rates of selfing and outcrossing in K. marmoratus and other mixed-mating species.
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